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Kenji Kawai, Takahiro Suzuki, Kenji Hayakawa; Investigation Of Long-term Transparency Of Acrysof®. Invest. Ophthalmol. Vis. Sci. 2011;52(14):6207.
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Glistening (brightness) which occurs in hydrophobic acrylic intraocular lenses is said to represent bubble formation associated with temperature changes. We performed an accelerated deterioration test of Acrysof® acrylic lenses, and concluded that glistening is not the only finding. In this study, we examined external appearance after simulated 10-year use and re-examined light transmittance using 20 pieces of Acrysof ®.
Acrysof®: Ten pieces of clear hydrophobic lenses (SA60AT) and 10 pieces of colored hydrophobic lenses (SN60AT) were used.We installed Acrysof® in a lens holder in a 30-ml screw tube bottle containing phosphate buffer, and allowed them to soak for 58 days at 100°C. We hypothesized that storage in a 100°C oven for 23 days is equivalent to 4 years at 37°C, and calculated that 10 years corresponded to 58 days. Thus, we examined time-related changes in the external appearance of the IOLs on stereoscopic microscopy, and determined light transmittance.
Observation of external appearance: The extent of glistening was severe in 5% and moderate in 95% of cases. All Acrysof® lenses became transparent after being dried for 48 hours. Light transmittance: Light transmittance of SA60AT decreased by 3.3% at 450 nm as compared with the value before acceleration. No significant differences were seen for SN60AT.
In the accelerated deterioration test, glistening was seen in all Acrysof® lenses. The difference in glistening was thought to be attributable to the difference in the affinity of polymer chains during cast molding production. All Acrysof® lenses became transparent after being dried, probably because aqueous droplets absorbed in the polymer were released. We plan to conduct further deterioration testing in the future.
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