April 2011
Volume 52, Issue 14
Free
ARVO Annual Meeting Abstract  |   April 2011
Investigation Of Long-term Transparency Of Acrysof®
Author Affiliations & Notes
  • Kenji Kawai
    Ophthalmology, Tokai Univ School of Medicine, Isehara, Japan
  • Takahiro Suzuki
    Ophthalmology, Tokai Univ School of Medicine, Isehara, Japan
  • Kenji Hayakawa
    Ophthalmology, Tokai Univ School of Medicine, Isehara, Japan
  • Footnotes
    Commercial Relationships  Kenji Kawai, Alcon (F); Takahiro Suzuki, Alcon (F); Kenji Hayakawa, Alcon (F)
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science April 2011, Vol.52, 6207. doi:
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      Kenji Kawai, Takahiro Suzuki, Kenji Hayakawa; Investigation Of Long-term Transparency Of Acrysof®. Invest. Ophthalmol. Vis. Sci. 2011;52(14):6207.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: : Glistening (brightness) which occurs in hydrophobic acrylic intraocular lenses is said to represent bubble formation associated with temperature changes. We performed an accelerated deterioration test of Acrysof® acrylic lenses, and concluded that glistening is not the only finding. In this study, we examined external appearance after simulated 10-year use and re-examined light transmittance using 20 pieces of Acrysof ®.

Methods: : Acrysof®: Ten pieces of clear hydrophobic lenses (SA60AT) and 10 pieces of colored hydrophobic lenses (SN60AT) were used.We installed Acrysof® in a lens holder in a 30-ml screw tube bottle containing phosphate buffer, and allowed them to soak for 58 days at 100°C. We hypothesized that storage in a 100°C oven for 23 days is equivalent to 4 years at 37°C, and calculated that 10 years corresponded to 58 days. Thus, we examined time-related changes in the external appearance of the IOLs on stereoscopic microscopy, and determined light transmittance.

Results: : Observation of external appearance: The extent of glistening was severe in 5% and moderate in 95% of cases. All Acrysof® lenses became transparent after being dried for 48 hours. Light transmittance: Light transmittance of SA60AT decreased by 3.3% at 450 nm as compared with the value before acceleration. No significant differences were seen for SN60AT.

Conclusions: : In the accelerated deterioration test, glistening was seen in all Acrysof® lenses. The difference in glistening was thought to be attributable to the difference in the affinity of polymer chains during cast molding production. All Acrysof® lenses became transparent after being dried, probably because aqueous droplets absorbed in the polymer were released. We plan to conduct further deterioration testing in the future.

Keywords: intraocular lens • clinical laboratory testing • refractive surgery: optical quality 
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