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Tomoko Okabe, Shinichiro Kobayakawa, Kohji Kakisu, Tetsuo Tochikubo; Evaluation Of Blood Component Adhesions On The Optical Surfaces In Rabbit Model. Invest. Ophthalmol. Vis. Sci. 2011;52(14):6208.
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Various cells and membrane formation were observed on the surface of intraocular lenses (IOLs) in proliferative diabetic retinopathy, frequently. To evaluate the blood component adhesions on the optical surfaces in a rabbit model.
Intraocular lenses (IOLs) were implanted subcutaneously in rabbits for 30 days. Those IOLs included hydrophobic acrylic and hydroxyethyl methacrylate hydrogel (HEMA) materials. Hydrophobic acrylic materials were MA60AC, ZA9003 and X-60. HEMA materials were HP60M and MI60. Scanning electron microscopy (SEM) and energy dispersive x-ray spectroscopy (EDS) were used. Those IOLs were explanted at one month for SEM/EDS analysis, also analyzed modulation transfer function (MTF).
The membrane formation based on albumin was noted on the optical surfaces of all IOLs at one month. 33% of X-60 (hydrophobic acrylic), and 67% of HP60M or MI60 (HEMA) had multiple fine granular deposits on the optics. Calcification was detected from those deposits using by EDS. The average MTF values of hydrophobic acrylic IOLs were 0.59, and of HEMA IOLs were 0.43 (p=0.08).
Calcification on the optical surfaces occurred in subcutaneous environment within one month. There were no significant differences between optical performances of IOLs with calcification and those without calcification.
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