April 2011
Volume 52, Issue 14
Free
ARVO Annual Meeting Abstract  |   April 2011
Analysis of Optical Side Effects of fs-Laser Therapy in the Human Presbyopic Lens Simulated With Modified Contact Lenses
Author Affiliations & Notes
  • Monika P. Reder
    Department of Ophthalmology, HELIOS Klinikum Erfurt, Erfurt, Germany
  • Marcus Blum
    Department of Ophthalmology, HELIOS Klinikum Erfurt, Erfurt, Germany
  • Stefan Schramm
    Biomedical Engineering & Informatics, Ilmenau University of Technology, Ilmenau, Germany
  • Bernd U. Seifert
    Biomedical Engineering & Informatics, Ilmenau University of Technology, Ilmenau, Germany
  • Roland Ackermann
    Institute of Applied Physics, Friedrich Schiller University, Jena, Germany
  • Robert Kammel
    Institute of Applied Physics, Friedrich Schiller University, Jena, Germany
  • Stefan Nolte
    Institute of Applied Physics, Friedrich Schiller University, Jena, Germany
  • Kathleen S. Kunert
    Department of Ophthalmology, HELIOS Klinikum Erfurt, Erfurt, Germany
  • Footnotes
    Commercial Relationships  Monika P. Reder, None; Marcus Blum, None; Stefan Schramm, None; Bernd U. Seifert, None; Roland Ackermann, None; Robert Kammel, None; Stefan Nolte, None; Kathleen S. Kunert, None
  • Footnotes
    Support  BMBF FKZ 13N8835A
Investigative Ophthalmology & Visual Science April 2011, Vol.52, 6215. doi:
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      Monika P. Reder, Marcus Blum, Stefan Schramm, Bernd U. Seifert, Roland Ackermann, Robert Kammel, Stefan Nolte, Kathleen S. Kunert; Analysis of Optical Side Effects of fs-Laser Therapy in the Human Presbyopic Lens Simulated With Modified Contact Lenses. Invest. Ophthalmol. Vis. Sci. 2011;52(14):6215.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: : In a single-blinded study, the optical side effects of a potential fs-laser therapy in presbyopic human lenses were tested. The simulation of this therapy was carried out by creating four different laser-patterns into standard contact lenses (CL).

Methods: : Comparative examinations between modified and standard contact lenses were performed on 28 subjects. The 56 eyes were divided into four groups according to the modification of the CL: ‘G1-LASIK-Simulation’, ‘G2-Presbyopia-Therapy-Simulation’, ‘G3-grid-without-variation’ and ‘G4-grid-with-variation’. Parameters differed in spot size, pulse energy and grid pattern. Visual acuity was measured with EDTRS-charts, contrast sensitivity with F.A.C.T.-charts and night vision with Mesotest II with/without glare. Forward scattered light was subjectively measured with the C-Quant (both instruments: Oculus Optikgeräte GmbH, Germany) and objectively with a modified wavefront-analyser WASCA-MOD (Carl Zeiss Meditec AG, Germany). A questionnaire detected subjective quality of vision during contact lens wear. Differences between modified and standard contact lenses as well as differences among the modifications were analysed.

Results: : The modified and standard contact lenses indicated no significant difference in visual acuity, contrast sensitivity and mesopic vision without glare. While wearing modified lenses with a regular grid (G1-G3), quality of vision decreased significantly by means of mesopic vision with glare and subjective/objective straylight. These three modifications also caused an impairment of the subjective quality of vision. In contrast, there was no significant difference between G4 (randomised grid) and standard CL’s.

Conclusions: : The increase of optical side effects was reproducibly dependent on the geometry of the laser-structure. A randomised grid induced the least limitation of vision. The study results are useful for planning possible laser-patterns in fs-laser therapy of the presbyopic lens.

Keywords: presbyopia • optical properties • laser 
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