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Jing Wang, Denise Descovich, Alvine Fansi, Paul J. Harasymowycz, Gisele Li, Mark R. Lesk; Correlation Between Corneal Hysteresis And Optic Disc Morphological Parameters In Normal And Glaucoma Patients. Invest. Ophthalmol. Vis. Sci. 2011;52(14):6257. doi: https://doi.org/.
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© ARVO (1962-2015); The Authors (2016-present)
To evaluate the association between anterior segment parameters, such as central corneal thickness (CCT), corneal hysteresis (CH) and corneal resistance factor (CRF), and optic disc morphology in a cohort of adult patients.
Cross-sectional study. A cohort of subjects with diagnoses ranging from normal (N), glaucoma suspects (GS), mild to advanced open-angle glaucoma (OAG) and OHT were recruited. For each subject, we measured, in one single session, intraocular pressure (IOP) using Goldmann tonometer, CCT, CH and CRF using Ocular Response Analyzer, and axial length (AL). Historical untreated maximal IOP was also recorded for OAG and OHT subjects. Optic nerve head (ONH) morphology of each subject was assessed using Heidelberg Retina Tomography (HRT III). Pearson correlation analysis was performed between ONH morphology parameters and anterior segment parameters.
261 patients were included in the study (112 OAG; 52 GS; 44 OHT; 53 N). Mean cup depth (MCD) correlated moderately but significantly with CH (r = - 0.201, p = 0.001), CRF (r = - 0.163, p = 0.01), IOPmax (r = 0.162, p = 0.01), and CCT (r = - 0.160, p = 0.01), but it did not correlate with AL (p = 0.87) and current IOP (p = 0.33). Disc area (DA) only weakly correlated with CRF (r = -0.170, p = 0.007); Linear cup-to-disc-ratio (LCDR) correlated moderately with CH (r = - 0.341, p < 0.001) and CRF (r = - 0.366, p<0.001), and correlated weakly with AL (r=0.130, p=0.04), CCT (r = - 0.177, p = 0.005) and historical IOPmax (r = 0.168, p = 0.008).
Anterior segment parameters such as CH, CRF may provide insight into the morphology of posterior segment. This association supports previous reports on the association between a lower CH and glaucomatous damage.
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