April 2011
Volume 52, Issue 14
ARVO Annual Meeting Abstract  |   April 2011
Correlation Between Corneal Hysteresis And Optic Disc Morphological Parameters In Normal And Glaucoma Patients
Author Affiliations & Notes
  • Jing Wang
    Ophthalmology/MRH Research, University of Montreal, Sherbrooke, Quebec, Canada
  • Denise Descovich
    Ophthalmology-Montreal University, Hopital Maisonneuve-Rosemont, Montreal, Quebec, Canada
  • Alvine Fansi
    Ophthalmology/MRH Research,
    University of Montreal, Montreal, Quebec, Canada
  • Paul J. Harasymowycz
    Ophthalmology, Maisonneuve-Rosemont Hospital, Montreal, Quebec, Canada
  • Gisele Li
    University of Montreal, Montreal, Quebec, Canada
  • Mark R. Lesk
    Department of Ophthalmology,
    University of Montreal, Montreal, Quebec, Canada
  • Footnotes
    Commercial Relationships  Jing Wang, None; Denise Descovich, None; Alvine Fansi, None; Paul J. Harasymowycz, None; Gisele Li, None; Mark R. Lesk, None
  • Footnotes
    Support  FRSQ, CGCRC-CNIB
Investigative Ophthalmology & Visual Science April 2011, Vol.52, 6257. doi:
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      Jing Wang, Denise Descovich, Alvine Fansi, Paul J. Harasymowycz, Gisele Li, Mark R. Lesk; Correlation Between Corneal Hysteresis And Optic Disc Morphological Parameters In Normal And Glaucoma Patients. Invest. Ophthalmol. Vis. Sci. 2011;52(14):6257.

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      © ARVO (1962-2015); The Authors (2016-present)

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Purpose: : To evaluate the association between anterior segment parameters, such as central corneal thickness (CCT), corneal hysteresis (CH) and corneal resistance factor (CRF), and optic disc morphology in a cohort of adult patients.

Methods: : Cross-sectional study. A cohort of subjects with diagnoses ranging from normal (N), glaucoma suspects (GS), mild to advanced open-angle glaucoma (OAG) and OHT were recruited. For each subject, we measured, in one single session, intraocular pressure (IOP) using Goldmann tonometer, CCT, CH and CRF using Ocular Response Analyzer, and axial length (AL). Historical untreated maximal IOP was also recorded for OAG and OHT subjects. Optic nerve head (ONH) morphology of each subject was assessed using Heidelberg Retina Tomography (HRT III). Pearson correlation analysis was performed between ONH morphology parameters and anterior segment parameters.

Results: : 261 patients were included in the study (112 OAG; 52 GS; 44 OHT; 53 N). Mean cup depth (MCD) correlated moderately but significantly with CH (r = - 0.201, p = 0.001), CRF (r = - 0.163, p = 0.01), IOPmax (r = 0.162, p = 0.01), and CCT (r = - 0.160, p = 0.01), but it did not correlate with AL (p = 0.87) and current IOP (p = 0.33). Disc area (DA) only weakly correlated with CRF (r = -0.170, p = 0.007); Linear cup-to-disc-ratio (LCDR) correlated moderately with CH (r = - 0.341, p < 0.001) and CRF (r = - 0.366, p<0.001), and correlated weakly with AL (r=0.130, p=0.04), CCT (r = - 0.177, p = 0.005) and historical IOPmax (r = 0.168, p = 0.008).

Conclusions: : Anterior segment parameters such as CH, CRF may provide insight into the morphology of posterior segment. This association supports previous reports on the association between a lower CH and glaucomatous damage.

Keywords: optic nerve 

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