April 2011
Volume 52, Issue 14
ARVO Annual Meeting Abstract  |   April 2011
Variations in Corneal Biomechanics during the Menstrual Cycle in Glaucomatous and Age-matched Eyes
Author Affiliations & Notes
  • Michael Haustein
    Dept Ophthalmology,
    University of Dresden, Dresden, Germany
  • Frieder Meier
    Dept Ophthalmology,
    University of Dresden, Dresden, Germany
  • Lutz E. Pillunat
    Dept of Ophthalmology,
    University of Dresden, Dresden, Germany
  • Eberhard Spoerl
    University of Dresden, Dresden, Germany
  • Footnotes
    Commercial Relationships  Michael Haustein, None; Frieder Meier, None; Lutz E. Pillunat, None; Eberhard Spoerl, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science April 2011, Vol.52, 6261. doi:
  • Views
  • Share
  • Tools
    • Alerts
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      Michael Haustein, Frieder Meier, Lutz E. Pillunat, Eberhard Spoerl; Variations in Corneal Biomechanics during the Menstrual Cycle in Glaucomatous and Age-matched Eyes. Invest. Ophthalmol. Vis. Sci. 2011;52(14):6261.

      Download citation file:

      © ARVO (1962-2015); The Authors (2016-present)

  • Supplements

Purpose: : Our aim was to access the changes in corneal biomechanics during various phases of the menstrual cycle (MC) in glaucomatous and age matched healthy eyes.

Methods: : In this prospective study the corneal parameters of 15 female glaucoma patients (43 ± 5.5 years) of reproductive age were measured by Ocular Response Analyzer (Reichert Ophthalmic instruments, NY, USA) and compared with these of age matched healthy women. The corneal hysteresis (CH) and corneal resistance factor (CRF) were measured at 3 time points in their menstrual cycle, day 1 to 3, at ovulation (approximately day 15) and at day 25 to 28. Ovulation was determined with a test that records the peak of luteinizing hormone in the urine. In addition, corneal thickness (CCT) and intraocular pressure (IOP) were determined.

Results: : CH in the glaucoma patients was lowest at the beginning of the cycle (mean = 10.0 mmHg), increased statistically significantly at ovulation (mean = 10.7 mmHg, P= 0.033) but not at the end of the cycle (mean = 10.5 mmHg, P=0.45). CRF (11.4 mmHg) stayed at the same level during MC (P=0.101). In comparison of the both groups glaucoma showed a significant lower CH (10.07 mmHg vs. 11.367 mmHg; P=0.024) at the beginning of the cycle. There were no statistically significant differences between the groups in CRF (P=0.55). In addition, CCT and IOPg showed no statistically significant changes. IOPcc changed significantly from 17.3 mmHg to 16.4 mmHg to 16.9 mmHg in the glaucoma group, respectively. There were no differences between the groups. The difference in IOPcc was statistically significant at ovulation (P=0.024) in comparison with the baseline.

Conclusions: : During the menstrual cycle corneal parameters change in healthy and also in glaucoma. CH but not CRF decrease at the middle of the menstrual cycle. The physiological estrogen level is in this period of MC at the top. Therefore, these results could be secondary to hormonal influences suggesting that reduced estrogen may play a role in glaucoma pathogenesis.

Keywords: cornea: clinical science • clinical (human) or epidemiologic studies: systems/equipment/techniques • clinical (human) or epidemiologic studies: risk factor assessment 

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.