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Rajesh Sasikumar, Sathidevi A. V, Dhanraj A. Rao, Narendra K. P, Ramgopal Balu, Dipali Prabhu, Tin Aung, Bhujang K. Shetty; Lens Vault in Asian Indian Eyes with Angle Closure. Invest. Ophthalmol. Vis. Sci. 2011;52(14):6272.
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© ARVO (1962-2015); The Authors (2016-present)
To measure lens vault (LV) in Asian Indian eyes with angle closure.
In this prospective observational comparative study, subjects with primary angle closure (including angle closure suspects (PACS), angle closure (PAC) and angle closure glaucoma (PACG)) and normals were enrolled. All subjects underwent gonioscopy and imaging with Fourier-domain source-swept anterior-segment optical coherence tomography (SSOCT; Tomey, Japan). LV was defined as the perpendicular distance between the anterior pole of the crystalline lens and the horizontal line joining the 2 scleral spurs (SS). It was measured manually, after marking the SS, in both horizontal and vertical scans. Imaging was performed prior to laser iridotomy.
Ninety-five eyes (62 subjects) with gradable images (determined by scleral spur detection) were analyzed; 51 eyes (39 subjects) had angle closure and 44 eyes (23 normal subjects) had open angles. LV was found to be significantly greater in angle closure eyes compared to normal eyes for both horizontal (782.1 µ, 95% C.I, 726.4-837.8, vs. 526.9 µ, 95% C.I, 486.2-567.6) (p<0.0001) and vertical (825.9 µ, 95% C.I, 780.2-871.6 vs. 589.3 µ, 95% C.I, 538.2-640.4) (P0.05) for scans from either meridian. Intra-class correlation for intra-observer reliability for measuring LV was 0.87 (95% C.I, 0.74-0.92).
In this cohort of Asian Indians, LV was greater in angle closure eyes when compared to normal eyes. This parameter might be a determinant in angle closure pathogenesis.
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