April 2011
Volume 52, Issue 14
Free
ARVO Annual Meeting Abstract  |   April 2011
Lens Vault in Asian Indian Eyes with Angle Closure
Author Affiliations & Notes
  • Rajesh Sasikumar
    Glaucoma, Narayana Nethralaya Eye Hospital, Bangalore, India
  • Sathidevi A. V
    Glaucoma, Narayana Nethralaya Eye Hospital, Bangalore, India
  • Dhanraj A. Rao
    Glaucoma, Narayana Nethralaya Eye Hospital, Bangalore, India
  • Narendra K. P
    Glaucoma, Narayana Nethralaya Eye Hospital, Bangalore, India
  • Ramgopal Balu
    Glaucoma, Narayana Nethralaya Eye Hospital, Bangalore, India
  • Dipali Prabhu
    Glaucoma, Narayana Nethralaya Eye Hospital, Bangalore, India
  • Tin Aung
    Glaucoma, Singapore National Eye Center, Singapore, Singapore
  • Bhujang K. Shetty
    Glaucoma, Narayana Nethralaya Eye Hospital, Bangalore, India
  • Footnotes
    Commercial Relationships  Rajesh Sasikumar, None; Sathidevi A. V, None; Dhanraj A. Rao, None; Narendra K. P, None; Ramgopal Balu, None; Dipali Prabhu, None; Tin Aung, None; Bhujang K. Shetty, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science April 2011, Vol.52, 6272. doi:
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      Rajesh Sasikumar, Sathidevi A. V, Dhanraj A. Rao, Narendra K. P, Ramgopal Balu, Dipali Prabhu, Tin Aung, Bhujang K. Shetty; Lens Vault in Asian Indian Eyes with Angle Closure. Invest. Ophthalmol. Vis. Sci. 2011;52(14):6272.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: : To measure lens vault (LV) in Asian Indian eyes with angle closure.

Methods: : In this prospective observational comparative study, subjects with primary angle closure (including angle closure suspects (PACS), angle closure (PAC) and angle closure glaucoma (PACG)) and normals were enrolled. All subjects underwent gonioscopy and imaging with Fourier-domain source-swept anterior-segment optical coherence tomography (SSOCT; Tomey, Japan). LV was defined as the perpendicular distance between the anterior pole of the crystalline lens and the horizontal line joining the 2 scleral spurs (SS). It was measured manually, after marking the SS, in both horizontal and vertical scans. Imaging was performed prior to laser iridotomy.

Results: : Ninety-five eyes (62 subjects) with gradable images (determined by scleral spur detection) were analyzed; 51 eyes (39 subjects) had angle closure and 44 eyes (23 normal subjects) had open angles. LV was found to be significantly greater in angle closure eyes compared to normal eyes for both horizontal (782.1 µ, 95% C.I, 726.4-837.8, vs. 526.9 µ, 95% C.I, 486.2-567.6) (p<0.0001) and vertical (825.9 µ, 95% C.I, 780.2-871.6 vs. 589.3 µ, 95% C.I, 538.2-640.4) (P0.05) for scans from either meridian. Intra-class correlation for intra-observer reliability for measuring LV was 0.87 (95% C.I, 0.74-0.92).

Conclusions: : In this cohort of Asian Indians, LV was greater in angle closure eyes when compared to normal eyes. This parameter might be a determinant in angle closure pathogenesis.

Keywords: imaging methods (CT, FA, ICG, MRI, OCT, RTA, SLO, ultrasound) • imaging/image analysis: clinical 
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