April 2011
Volume 52, Issue 14
ARVO Annual Meeting Abstract  |   April 2011
Lens Vault as a Risk Factor for Angle Closure in Japanese
Author Affiliations & Notes
  • Mineo Ozaki
    Ophthalmology, Ozaki Eye Hosp, Hyuga, Japan
  • Takanori Mizoguchi
    Ophthalmology, Mizoguchi Eye Hosp, Sasebo, Japan
  • Monisha E. Nongpiur
    Singapore Eye Research Institute and Singapore National Eye Center, Singapore, Singapore
  • Tin Aung
    Singapore Eye Research Institute and Singapore National Eye Center, Singapore, Singapore
  • Footnotes
    Commercial Relationships  Mineo Ozaki, None; Takanori Mizoguchi, None; Monisha E. Nongpiur, None; Tin Aung, Carl Zeiss Meditec (F)
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science April 2011, Vol.52, 6273. doi:
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      Mineo Ozaki, Takanori Mizoguchi, Monisha E. Nongpiur, Tin Aung; Lens Vault as a Risk Factor for Angle Closure in Japanese. Invest. Ophthalmol. Vis. Sci. 2011;52(14):6273.

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      © ARVO (1962-2015); The Authors (2016-present)

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Lens Vault (LV) is defined as the perpendicular distance between the anterior pole of the crystalline lens and the horizontal line joining the two scleral spurs, on horizontal AS-OCT scans. It was recently identified as a new potential risk factor for angle closure in Chinese Singaporeans. The purpose of our study was to investigate the association of this parameter with angle closure in Japanese subjects.


Eighty-seven Japanese subjects with primary angle-closure (PAC) or primary angle-closure glaucoma (PACG), and 68 normal Japanese subjects were recruited. PAC was defined as the presence of appositional angle closure for ≥270 degrees with peripheral anterior synechiae and/ or raised intraocular pressure; PACG was defined as eyes with PAC associated with glaucomatous optic neuropathy. All participants underwent A-scan biometry and anterior-segment optical coherence tomography (AS-OCT). Customized software was used to measure LV. A-scan biometry was used to measure lens thickness (LT) and to calculate lens position (LP) and relative lens position (RLP).


There were no significant differences between the two groups for age (p=0.57). Compared to normal eyes, eyes with angle closure had significantly shallower ACD (p<0.001), shorter AL (p<0.001), greater LV (p<0.001) and LT (p<0.001), which were more anteriorly positioned (LP, p<0.001; RLP, p=0.008). After adjusting for age, gender, ACD, LT, and RLP, increased LV was associated significantly with angle closure (odds ratio [OR], 78.8; 95% confidence interval [CI], 6.4 -965.3, comparing lowest to highest quartile). LV had the highest AUC (0.96), higher than any other parameters.


Eyes with angle closure have shown greater LV compared with normal eyes. The LV, which represents the anterior portion of the lens, is a novel parameter strongly associated with angle closure in Japanese after adjusting for age, gender, ACD, and LT.  

Keywords: imaging/image analysis: clinical • clinical (human) or epidemiologic studies: risk factor assessment • anterior chamber 

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