April 2011
Volume 52, Issue 14
Free
ARVO Annual Meeting Abstract  |   April 2011
Combined Radial And Longitudinal Imaging Of Schlemm’S Canal In Eyes With Angle-closure Using Anterior Segment Fourier-domain OCT (ASFDOCT)
Author Affiliations & Notes
  • Tanya Albukh
    Ophthalmology, Einhorn Clinical Resarch Center, New York Eye and Ear Infirmary, New York, New York
  • Alfredo R. Castillejos
    Ophthalmology, Einhorn Clinical Resarch Center, New York Eye and Ear Infirmary, New York, New York
  • Saman Kiumehr
    Ophthalmology, Einhorn Clinical Resarch Center, New York Eye and Ear Infirmary, New York, New York
  • Syril K. Dorairaj
    Ophthalmology, Einhorn Clinical Resarch Center, New York Eye and Ear Infirmary, New York, New York
  • Carlos G. De Moraes
    Ophthalmology, Einhorn Clinical Resarch Center, New York Eye and Ear Infirmary, New York, New York
    Ophthalmology, New York University School of Medicine, New York, New York
  • Jeffrey M. Liebmann
    Ophthalmology, New York University School of Medicine, New York, New York
  • Robert Ritch
    Ophthalmology, Einhorn Clinical Resarch Center, New York Eye and Ear Infirmary, New York, New York
    Ophthalmology, New York Medical College, Valhalla, New York
  • Footnotes
    Commercial Relationships  Tanya Albukh, None; Alfredo R. Castillejos, None; Saman Kiumehr, None; Syril K. Dorairaj, None; Carlos G. De Moraes, None; Jeffrey M. Liebmann, Alcon Laboratories Inc, Allergan Inc, Carl Zeiss Meditec Inc, Diopsys Inc, Pfizer Inc, Topcon Medical System Inc (C), Diopsys Inc, Topcon Medical Systems Inc (F); Robert Ritch, Diopsys Inc, Pfizer Inc, Topcon Medical System Inc (C), Diopsys Inc, Topcon Medical Systems Inc (F)
  • Footnotes
    Support  Supported in part by the Arthur and Janet Herschaft Research Fund of the New York Glaucoma Research Institute
Investigative Ophthalmology & Visual Science April 2011, Vol.52, 6282. doi:
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      Tanya Albukh, Alfredo R. Castillejos, Saman Kiumehr, Syril K. Dorairaj, Carlos G. De Moraes, Jeffrey M. Liebmann, Robert Ritch; Combined Radial And Longitudinal Imaging Of Schlemm’S Canal In Eyes With Angle-closure Using Anterior Segment Fourier-domain OCT (ASFDOCT). Invest. Ophthalmol. Vis. Sci. 2011;52(14):6282.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract
 
Purpose:
 

To qualitatively and quantitatively assess the morphology of Schlemm’s canal(SC) in eyes with occludable angles successfully treated by laser iridotomy(LI) ± argon laser peripheral iridoplasty(ALPI) and normal eyes using ASFDOCT.

 
Methods:
 

20 normal subjects and 40 patients with occludable angles who 3-6 months prior had undergone an uneventful and successful LI ± ALPI relieving iridotrabecular contact were imaged using a standardized set of radial and longitudinal ASFDOCT scans of the nasal and temporal limbus. One eye per patient was randomly selected and the best image of each set was analyzed. SC area, length and width were assessed with the radial scan; and SC maximum and minimum width with the longitudinal scan. Eyes were grouped into those with appositional closure (group A n=18), synechial closure (group S n=22 PAS≤2 quadrants) or normals (group N n=20). The variables were compared among the 3 groups using a post hoc Bonferroni test. Spearman’s correlation coefficients were calculated to assess the relationship between SC morphometry and the maximum untreated IOP, number of medications, CDR, and PSD.

 
Results:
 

The groups were comparable in age (56±11years p=0.33). SC area (N=3210±1686 A=3500±1401 S=2000±1206 µm²), length (N=251, A=265, S=148 µm) and minimum longitudinal width (N=16±6, A=17±5 S=12±6 µm) were reduced in group S (all p<0.05). A negative correlation was found between SC morphometry (area, length, longitudinal minimum width) and CDR, IOP and the number of glaucoma medications (all p<.05).Qualitatively, SC in group S was visibly reduced, showing alternate areas of collapse.

 
Conclusions:
 

Combining longitudinal and radial scans provides a better assessment of the overall condition of SC. Synechial closure may eventually cause an irreversible reduction in SC dimensions even after iridotrabecular contact has been relieved.  

 
Keywords: anterior segment • imaging/image analysis: clinical • imaging methods (CT, FA, ICG, MRI, OCT, RTA, SLO, ultrasound) 
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