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Moon Hee Jeong, Eun Ji Lee, Tae-Woo Kim, Robert N. Weinreb, Ki Ho Park, Seok Hwan Kim, Dong Myung Kim; Anterior Movement of the Lamina Cribrosa after Trabeculectomy in Spectral-Domain Optical Coherence Tomography Image Series. Invest. Ophthalmol. Vis. Sci. 2011;52(14):6287.
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To investigate the changes in the location of lamina cribrosa and the thickness of prelaminar neural tissue after glaucoma surgery using spectral domain optical coherence tomography (SD-OCT).
Optic discs of the 31 glaucoma patients who underwent trabeculectomy were scanned using enhanced depth imaging SD-OCT before surgery and 1 week, 1 month, 3 months, 6 months and 9 months postoperatively. The pre- and postoperative magnitude of the lamina cribrosa bowing and the thickness of the prelaminar tissue were determined on B scan images which contains the mostly depressed lamina cribrosa.
Intraocular pressure (IOP) decreased from 28.1±9.2 mmHg (range: 14 to 47 mmHg) to 10.0±3.1 mmHg (range: 4 to 21 mmHg) over a mean follow-up of 4.7±2.6 months. The amount of posterior bowing of the lamina cribrosa was significantly decreased from a mean preoperative level of 646.48±171.10 µm to 541.90±141.17 µm at the end of follow-up (P<0.001). There was no significant change in the prelaminar neural tissue thickness (119.14±50.46 µm preoperatively, and 122.67±50.43 µm postoperatively, P=0.070). The magnitude of the lamina cribrosa movement was significantly associated with greater percent IOP reduction (P=0.003) and younger age (P<0.001).
Using enhanced depth imaging SD-OCT of the optic nerve head, the anterior movement of lamina cribrosa following glaucoma surgery was demonstrated. No significant thickness change was observed in the prelaminar neural tissue thickness.
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