April 2011
Volume 52, Issue 14
Free
ARVO Annual Meeting Abstract  |   April 2011
Orneal Microstrural Changes In Rhesus Monkeys Wearing Orthokeratology Contact Lenses For Myopia
Author Affiliations & Notes
  • Xingwu Zhong
    State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Ctr, Guangzhou, China
  • Hui Ding
    State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Ctr, Guangzhou, China
  • Hong He
    State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Ctr, Guangzhou, China
  • Shaohui Gao
    State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Ctr, Guangzhou, China
  • Footnotes
    Commercial Relationships  Xingwu Zhong, None; Hui Ding, None; Hong He, None; Shaohui Gao, None
  • Footnotes
    Support  This work was supported by a grant from the National Natural Science Foundation of China (81070754) and by the Fundamental Research Funds of State Key Lab.
Investigative Ophthalmology & Visual Science April 2011, Vol.52, 6292. doi:
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      Xingwu Zhong, Hui Ding, Hong He, Shaohui Gao; Orneal Microstrural Changes In Rhesus Monkeys Wearing Orthokeratology Contact Lenses For Myopia. Invest. Ophthalmol. Vis. Sci. 2011;52(14):6292.

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Abstract

Purpose: : This study compared the effect of orthokeratology(OK) lens wear on corneal topography and microstructure between the 1 night and 30 night wearers in order to predict any adverse responses of the eyes to long-term OK lens wear.

Methods: : Nine rhesus monkeys with one eye wearing an OK lens and the fellow eye wearing a rigid gas permeable lens (RGP) were used in this study. The lenses were worn for 11 hours with the measurement of corneal curvature and thickness, and axial components of the eye at 0 night (n=9), 1 night (n=9) and 30 nights (n=6). Histology was performed then.

Results: : Corneal surface power at 3mm central region was reduced in the OK eye when compared to the RGP eye (p<0.05). Central corneal thickness was only reduced in 30 nights of OK lens wear (p<0.05). Under light microscopy, the 1-night OK or RGP eyes showed normal morphology in all layers of the cornea. The 30-night OK eyes showed a thinned central corneal epithelium and a thickened but less stratified paracentral corneal epithelium when compared to the 30-night RGP eyes. Under electron microscopy, intercellular junctions of corneal epithelium in the 30-night OK eyes were much looser than in the 1-night OK eyes. However, the density and morphology of hemidesmosomes were similar between the OK and RGP eyes at 30 days of lens wear.

Conclusions: : Overnight orthokeratology can effectively correct myopia by changing the cornea curvature through anterior corneal remodeling. However, a decrease in inter-cellular junctions during a longterm wear may compromise the functions of the corneal epithelium as a frontier mechanical barrier.

Keywords: myopia • microscopy: electron microscopy • contact lens 
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