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Shi Zhuan Tan, Catherine Dhaliwal, Brian W. Fleck; Trends In The Incidence Of Retinopathy Of Prematurity In Lothian, Scotland In The Past 20 Years. Invest. Ophthalmol. Vis. Sci. 2011;52(14):6324.
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To report the trends in incidence of retinopathy of prematurity (ROP) within Lothian, a geographically defined region in southeast Scotland over a 20-year period from 1990 to 2009.
An observational cohort study of all babies with gestational age<32 weeks and/or birth weight<1500 g born to mothers resident in Lothian between 1 January 1990 and 31 December 2009 was conducted. Eligible babies underwent eye screening by two experienced paediatric ophthalmologists. Lothian population data were obtained from the Scottish Health Service. The trends in survival rates, incidence and treatment of ROP were analysed in 4 epochs: 1990 to 1994, 1995 to 1999, 2000 to 2004 and 2005 to 2009. Chi-square trend test was used to calculate statistical significance.
The proportion of babies born with birth weight<1500 g and/or gestational age<32 weeks has remained constant in the past 20 years but the proportion of these babies surviving to 42 weeks corrected gestation were found to have increased significantly (p<0.001). A total of 1922 eligible babies were screened for ROP. There was no significant change in trend in the number of babies with ROP throughout the study period but a statistically significant linear trend towards a reduction in the number of babies with severe ROP and babies undergoing treatment for ROP were observed (p=0.01, p=0.04, respectively). There was also a trend towards more babies with no ROP in the birth weight < 750g group (p=0.02) and gestational age ≤ 24 weeks group (p=0.05).
A significant reduction in the number of babies with severe ROP and babies treated for ROP has been observed in the Lothian region of southeast Scotland over the past 20 years.
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