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Sul Gee Lee, Jae Wook Yang, Dong Sik Ham, Byung Gun Park, Byoung Hyun Min; The Effect of Cornifilm on Wound Adhesions in Rabbit Experimental Surgery. Invest. Ophthalmol. Vis. Sci. 2011;52(14):6355.
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Adhesions after strabismus surgery may alter surgical outcome. Our study performed to evaluate the antiadhesive effect of Cornifilm, bio-membrane extracted from pig cartilage ECM (extracelluar matrix) component in strabismus surgery.
Nine adult female New Zealand White rabbits (18 eyes) were used. The superior rectus muscle (SRM) was recessed 3mm on both eyes with limbal incision. In one eye of each rabbit, 6x6 mm sized Cornifilm was inserted beneath and over the recessed SRM. The fellow eye of each rabbit (control group) underwent only SRM recession without Cornifilm. After 6 weeks, both eyes of rabbits were enucleated. Histologic examination was performed to evaluate the degree of inflammation and fibrosis, with hematoxylin-eosin and Masson’s trichrome staining. In all eyes, one masked observer evaluated the severity of adhesion by dissection of surgery area.
Compared with control eyes, Cornifilm application group showed less adhesion between conjunctiva, sclear and SRM significantly (p<0.05). On Histologic examination, there were also significant less fibrosis and inflammation occurred on Cornifilm used group (p<0.05).
This study shows that use of Cornifilm effectively reduced postoperative adhesions and inflammations around surgical area. Use of Cornifilm may help maintaining more stable angle after strabismus surgery
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