April 2011
Volume 52, Issue 14
Free
ARVO Annual Meeting Abstract  |   April 2011
Quantifying Diplopia Using a Patient-reported Outcome Questionnaire
Author Affiliations & Notes
  • Stephen J. Smith
    Mayo Medical School,
    Mayo Clinic, Rochester, Minnesota
  • Laura Liebermann
    Ophthalmology,
    Mayo Clinic, Rochester, Minnesota
  • Sarah R. Hatt
    Ophthalmology,
    Mayo Clinic, Rochester, Minnesota
  • David A. Leske
    Ophthalmology,
    Mayo Clinic, Rochester, Minnesota
  • Jonathan M. Holmes
    Ophthalmology,
    Mayo Clinic, Rochester, Minnesota
  • Footnotes
    Commercial Relationships  Stephen J. Smith, None; Laura Liebermann, None; Sarah R. Hatt, None; David A. Leske, None; Jonathan M. Holmes, None
  • Footnotes
    Support  NIH Grants EY015799 and EY018810, and Research to Prevent Blindness
Investigative Ophthalmology & Visual Science April 2011, Vol.52, 6361. doi:
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      Stephen J. Smith, Laura Liebermann, Sarah R. Hatt, David A. Leske, Jonathan M. Holmes; Quantifying Diplopia Using a Patient-reported Outcome Questionnaire. Invest. Ophthalmol. Vis. Sci. 2011;52(14):6361.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: : We have previously described a diplopia questionnaire that rates diplopia on a 3-point scale (never, sometimes, always) in specific positions of gaze. Using this questionnaire in clinical practice suggested a need for additional response categories. Specifically, patients with rare diplopia were often unable to decide between never and sometimes and patients with frequent diplopia were often able to decide between sometimes and always. We therefore tested a revised diplopia questionnaire (RDQ) adding categories of rarely and often, to yield 5 levels (never, rarely, sometimes, often, always) for each gaze position (reading, straight ahead distance, down, right, left, up, and other).

Methods: : 94 consecutive adult strabismus patients completed the RDQ at their office visit. In 17 (15%) of these patients, the questionnaire was completed again one week later (range 1 to 68 days) to evaluate test-retest reliability. Possible scores ranged from 0 (no diplopia) to 100 (diplopia always in all positions of gaze), weighted to straight ahead distance and reading. We evaluated the frequency of using rarely and often responses, the overall distribution of scores, and test-retest reliability by Intraclass Correlation Coefficient (ICC).

Results: : The new response options of rarely and often were used by 44 (47%) of 94 patients. Scores were distributed between 0 to 100, with 4% to 23% in each decile, indicating use of the whole range. Test-retest reliability was excellent, with an ICC of 0.92 (95% CI 0.79 to 0.97).

Conclusions: : The Revised Diplopia Questionnaire (incorporating rarely and often response options) appears useful in quantifying diplopia and has excellent test-retest reliability. This questionnaire provides a standardized method for patients to record their symptoms of diplopia and therefore is useful in clinical practice. Additionally, the Revised Diplopia Questionnaire score provides a quantitative outcome measure for future clinical studies.

Keywords: strabismus • strabismus: diagnosis and detection • strabismus: treatment 
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