April 2011
Volume 52, Issue 14
Free
ARVO Annual Meeting Abstract  |   April 2011
Patterns Of Neovascularization In Intrastromal Ring Segment Surgery In An Animal Model
Author Affiliations & Notes
  • Roberto Cantalapiedra
    Biologia Celular e Histologia, University of Valladolid, Valladolid, Spain
  • L. Ibares
    Biologia Celular e Histologia, University of Valladolid, Valladolid, Spain
  • P. Gallego
    Biologia Celular e Histologia, University of Valladolid, Valladolid, Spain
  • J. Merayo-Lloves
    Biologia Celular e Histologia, University of Valladolid, Valladolid, Spain
    Fundacion de Investigacion Oftalmologica Fernandez-Vega, Oviedo, Spain
  • M.C. Martinez-Garcia
    Biologia Celular e Histologia, University of Valladolid, Valladolid, Spain
  • Footnotes
    Commercial Relationships  Roberto Cantalapiedra, None; L. Ibares, None; P. Gallego, None; J. Merayo-Lloves, None; M.C. Martinez-Garcia, None
  • Footnotes
    Support  Spanish Ministry of Science and Innovation (PROFIT CIT-300100-2007-50).
Investigative Ophthalmology & Visual Science April 2011, Vol.52, 6381. doi:
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      Roberto Cantalapiedra, L. Ibares, P. Gallego, J. Merayo-Lloves, M.C. Martinez-Garcia; Patterns Of Neovascularization In Intrastromal Ring Segment Surgery In An Animal Model. Invest. Ophthalmol. Vis. Sci. 2011;52(14):6381.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: : To Study the incidence of neovascularization following intrastromal ring segment surgery in an animal model and to evaluate differents patterns showed .

Methods: : We performed surgery in 22 hens (44 eyes). We implanted one intrastromal ring segment in each eye by manual Ferrara technique. We followed clinically the animals daily the first week and then on days 7, 15 and 1, 2, 3 and 6 months. We randomly divided the hens into groups of 4 related to time of euthanized for histopatological analisis with hematoxilin eosin

Results: : We found clinically neovascularization in 7 eyes, in 4 the new vessels came from the superficial limbus near the incision in a branched way. In the other 3 eyes we observed neovascularization which passed deep and branched from limbus to all the segment lenghtAs regards histological analysis we found neovascularization near the incisión in the first group and following the outer edge of the segment in second group. We also found limbus neovascularization in 50% of the hens euthanized later than 1 month of following.

Conclusions: : We show differents patterns of neovascularization not shown before in humans.Histologically neovascularization showed in this study could explain long term complications.

Keywords: cornea: clinical science • wound healing • neovascularization 
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