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Roberto Cantalapiedra, L. Ibares, P. Gallego, J. Merayo-Lloves, M.C. Martinez-Garcia; Patterns Of Neovascularization In Intrastromal Ring Segment Surgery In An Animal Model. Invest. Ophthalmol. Vis. Sci. 2011;52(14):6381.
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To Study the incidence of neovascularization following intrastromal ring segment surgery in an animal model and to evaluate differents patterns showed .
We performed surgery in 22 hens (44 eyes). We implanted one intrastromal ring segment in each eye by manual Ferrara technique. We followed clinically the animals daily the first week and then on days 7, 15 and 1, 2, 3 and 6 months. We randomly divided the hens into groups of 4 related to time of euthanized for histopatological analisis with hematoxilin eosin
We found clinically neovascularization in 7 eyes, in 4 the new vessels came from the superficial limbus near the incision in a branched way. In the other 3 eyes we observed neovascularization which passed deep and branched from limbus to all the segment lenghtAs regards histological analysis we found neovascularization near the incisión in the first group and following the outer edge of the segment in second group. We also found limbus neovascularization in 50% of the hens euthanized later than 1 month of following.
We show differents patterns of neovascularization not shown before in humans.Histologically neovascularization showed in this study could explain long term complications.
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