April 2011
Volume 52, Issue 14
Free
ARVO Annual Meeting Abstract  |   April 2011
Can Systemic Markers Of Inflammation Predict Subtypes Of Age Related Macular Degeneration?
Author Affiliations & Notes
  • Lyndell L. Lim
    Centre for Eye Research, University of Melbourne, East Melbourne, Australia
  • Rachel Goh
    Centre for Eye Research, University of Melbourne, East Melbourne, Australia
  • Celestine Wong
    Centre for Eye Research, University of Melbourne, East Melbourne, Australia
  • Tania Cipriani
    Centre for Eye Research, University of Melbourne, East Melbourne, Australia
  • Luba Robman
    Centre for Eye Research, University of Melbourne, East Melbourne, Australia
  • Lucy Busija
    Centre for Eye Research, University of Melbourne, East Melbourne, Australia
  • Robyn H. Guymer
    Centre for Eye Research, University of Melbourne, East Melbourne, Australia
  • Footnotes
    Commercial Relationships  Lyndell L. Lim, None; Rachel Goh, None; Celestine Wong, None; Tania Cipriani, None; Luba Robman, None; Lucy Busija, None; Robyn H. Guymer, None
  • Footnotes
    Support  ORIA Research Grant 2009, Eye Foundation Fellowship Grant (Australia) 2008
Investigative Ophthalmology & Visual Science April 2011, Vol.52, 6637. doi:
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      Lyndell L. Lim, Rachel Goh, Celestine Wong, Tania Cipriani, Luba Robman, Lucy Busija, Robyn H. Guymer; Can Systemic Markers Of Inflammation Predict Subtypes Of Age Related Macular Degeneration?. Invest. Ophthalmol. Vis. Sci. 2011;52(14):6637.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: : Age-related macular degeneration (AMD) is now postulated to be the result of a chronic inflammatory process. We investigated the possible association between a range of systemic inflammatory biomarkers with each of the subtypes of AMD.

Methods: : This was a cross-sectional study involving 236 patients from the Royal Victorian Eye & Ear Hospital and community volunteers from July 2008 to May 2009. As determined by fundus photography and angiography (as indicated) 46 had early AMD, 24 had geographic atrophy (GA), 124 had choroidal neovascularisation (CNV) and 42 were controls. Investigated inflammatory markers included C-reactive protein, CC chemokine ligand-2/monocyte chemotactic protein-1 (CCL2/MCP-1), soluble intercellular adhesion molecule-1, interleukin-1β, interleukin-2, interleukin-6, tumor necrosis factor-alpha (TNF-α), and transforming growth factor-β1. Results were analysed with binary and multinomial logistic regression.

Results: : Mean levels of CCL2/MCP-1 differed between controls and all AMD (p=0.007). In subgroup analysis, an inverse relationship was found between the levels of CCL2/MCP-1 with both GA (OR = 0.989, 95% CI = 0.975 - 0.996, p = 0.008) and CNV (OR = 0.990, 95% CI = 0.981 - 0.999, p = 0.025). A similar inverse relationship was found between levels of TNF-α and the presence of CNV (OR = 0.19, 95% CI = 0.06 - 0.69, p = 0.011).After adjusting for confounders such as age, gender, and intake of anti-inflammatory medication, multinomial logistic regression showed that CNV remained inversely related to levels of both CCL2/MCP-1 and TNF-α (OR 0.990, 95% CI 0.977-0.998, p=0.017 and OR 0.553, 95% CI 0.333-0.919, p=0.022 respectively). No significant associations were found with the other cytokines.

Conclusions: : CCL2/MCP-1 and TNF-α appear to be associated with specific subsets of AMD. This reaffirms a role of inflammation in the pathogenesis of AMD and the possibility that these, and other inflammatory biomarkers may have a future role in monitoring AMD.

Keywords: age-related macular degeneration • clinical laboratory testing • clinical (human) or epidemiologic studies: risk factor assessment 
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