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Akira Meguro, Jeewon Mok, Takahiro Yamane, Akira Oka, Eiichi Okada, Etsuko Shibuya, Masao Ota, Shigeaki Ohno, Hidetoshi Inoko, Nobuhisa Mizuki; Genome-wide Association Study Of High Myopia Using 27,158 Microsatellite Markers. Invest. Ophthalmol. Vis. Sci. 2011;52(14):6662.
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To identify susceptibility genes for high myopia, we conducted a genome-wide association study (GWAS) in a Japanese population.
We conducted a GWAS in 1,040 Japanese individuals (520 patients and 520 controls) using a dense panel of 27,158 microsatellite markers covering the entire genome. After the microsatellite analysis, to validate the results, we performed SNP genotyping of the candidate loci for replication.
This GWAS led to identify four loci associated with high myopia. These four were localized to 2p21, 3q12.3, 3q21.1 and 15q14.
In this study, we were able to identify four susceptibility loci for high myopia, suggesting that the genes in these loci may play an important role in the development of high myopia.
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