April 2011
Volume 52, Issue 14
Free
ARVO Annual Meeting Abstract  |   April 2011
Genome-wide Association Study Of High Myopia Using 27,158 Microsatellite Markers
Author Affiliations & Notes
  • Akira Meguro
    Department of Ophthalmology, Yokohama City Univ School of Med, Yokohama, Japan
  • Jeewon Mok
    Department of Molecular Life Science, Division of Molecular Medical Science and Molecular Medicine, Tokai Univ School of Med, Isehara, Japan
    Laboratory of Ophthalmology and Visual Science, Catholic Research Institute of Medical Science, Catholic Univ of Korea, Seoul, Republic of Korea
  • Takahiro Yamane
    Department of Ophthalmology, Yokohama City Univ School of Med, Yokohama, Japan
  • Akira Oka
    Department of Molecular Life Science, Division of Molecular Medical Science and Molecular Medicine, Tokai Univ School of Med, Isehara, Japan
  • Eiichi Okada
    Okada Eye Clinic, Yokohama, Japan
  • Etsuko Shibuya
    Department of Ophthalmology, Yokohama City Univ School of Med, Yokohama, Japan
  • Masao Ota
    Department of Legal Medicine, Shinshu Univ School of Med, Matsumoto, Japan
  • Shigeaki Ohno
    Department of Ocular Inflammation and Immunology, Hokkaido Univ Graduate School of Med, Sapporo, Japan
  • Hidetoshi Inoko
    Department of Molecular Life Science, Division of Molecular Medical Science and Molecular Medicine, Tokai Univ School of Med, Isehara, Japan
  • Nobuhisa Mizuki
    Department of Ophthalmology, Yokohama City Univ School of Med, Yokohama, Japan
  • Footnotes
    Commercial Relationships  Akira Meguro, None; Jeewon Mok, None; Takahiro Yamane, None; Akira Oka, None; Eiichi Okada, None; Etsuko Shibuya, None; Masao Ota, None; Shigeaki Ohno, None; Hidetoshi Inoko, None; Nobuhisa Mizuki, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science April 2011, Vol.52, 6662. doi:
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      Akira Meguro, Jeewon Mok, Takahiro Yamane, Akira Oka, Eiichi Okada, Etsuko Shibuya, Masao Ota, Shigeaki Ohno, Hidetoshi Inoko, Nobuhisa Mizuki; Genome-wide Association Study Of High Myopia Using 27,158 Microsatellite Markers. Invest. Ophthalmol. Vis. Sci. 2011;52(14):6662.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: : To identify susceptibility genes for high myopia, we conducted a genome-wide association study (GWAS) in a Japanese population.

Methods: : We conducted a GWAS in 1,040 Japanese individuals (520 patients and 520 controls) using a dense panel of 27,158 microsatellite markers covering the entire genome. After the microsatellite analysis, to validate the results, we performed SNP genotyping of the candidate loci for replication.

Results: : This GWAS led to identify four loci associated with high myopia. These four were localized to 2p21, 3q12.3, 3q21.1 and 15q14.

Conclusions: : In this study, we were able to identify four susceptibility loci for high myopia, suggesting that the genes in these loci may play an important role in the development of high myopia.

Keywords: genetics • myopia • gene screening 
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