April 2011
Volume 52, Issue 14
Free
ARVO Annual Meeting Abstract  |   April 2011
Adjustable Tamponade: Could It Improve The Existing Retinal Tamponades And Thus Reduce PVR? Experimental Study
Author Affiliations & Notes
  • Jean-Marie A. Parel
    Ophthalmic Biophysics Center, Bascom Palmer Eye Institute, Univ of Miami Miller School of Medicine, Miami, Florida
  • Maria Lipartiti
    AL.CHI.MI.A. S.R.L., Ponte San Nicolò (PD), Italy
  • Mariela C. Aguilar
    Ophthalmic Biophysics Center, Bascom Palmer Eye Institute, Univ of Miami Miller School of Medicine, Miami, Florida
  • Domenico Amato
    AL.CHI.MI.A. S.R.L., Ponte San Nicolò (PD), Italy
  • Cornelis Rowaan
    Ophthalmic Biophysics Center, Bascom Palmer Eye Institute, Univ of Miami Miller School of Medicine, Miami, Florida
  • Esdras Arrieta
    Ophthalmic Biophysics Center, Bascom Palmer Eye Institute, Univ of Miami Miller School of Medicine, Miami, Florida
  • Thomas A. Albini
    Ophthalmic Biophysics Center, Bascom Palmer Eye Institute, Univ of Miami Miller School of Medicine, Miami, Florida
  • Sander R. Dubovy, Jr.
    Ophthalmic Biophysics Center, Bascom Palmer Eye Institute, Univ of Miami Miller School of Medicine, Miami, Florida
  • Andrea Saitta
    University of Ancona, Ancona, Italy
  • Cesare Mariotti
    University of Ancona, Ancona, Italy
  • Footnotes
    Commercial Relationships  Jean-Marie A. Parel, None; Maria Lipartiti, AL.CHI.MI.A. S.R.L. (E); Mariela C. Aguilar, None; Domenico Amato, AL.CHI.MI.A. S.R.L. (E); Cornelis Rowaan, None; Esdras Arrieta, None; Thomas A. Albini, None; Sander R. Dubovy, Jr., None; Andrea Saitta, None; Cesare Mariotti, None
  • Footnotes
    Support  Florida Lions Eye Bank; Abeamed Inc; NIH Center Grant P30EY14801; Research to Prevent Blindness; Henri and Flore Lesieur Foundation (JMP).
Investigative Ophthalmology & Visual Science April 2011, Vol.52, 6687. doi:
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      Jean-Marie A. Parel, Maria Lipartiti, Mariela C. Aguilar, Domenico Amato, Cornelis Rowaan, Esdras Arrieta, Thomas A. Albini, Sander R. Dubovy, Jr., Andrea Saitta, Cesare Mariotti; Adjustable Tamponade: Could It Improve The Existing Retinal Tamponades And Thus Reduce PVR? Experimental Study. Invest. Ophthalmol. Vis. Sci. 2011;52(14):6687.

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Abstract

Purpose: : To examine the possibility of modifying the tamponade density after vitreoretinal surgery, with the aim of reducing the limitations of current tamponades.

Methods: : A microprocessor controlled motorized artificial eye (Ocular Saccades Simulator, OSS) was designed to simulate saccadic eye movements and used to study the chemical kinetics necessary to obtain a heavy silicone oil from a light-one. The artificial eye was filled with a solution of porcine serum that mimics aqueous component and a 1000cS silicone oil. The heavier-than-water, highly biocompatible perfluoroalkyloxy octane agent was then added in a 25% proportion to silicone oil to obtain a final density of 1.03 g/cm3 and the OSS set in motion for 48hrs. To study fluid dynamics during the time-course, a digital camera captured images at programmed intervals.

Results: : At time zero, serum was observed at the interface between perfluoroalkyloxy octane (bottom) and silicone oil (top). The serum moved gradually to the top of the artificial eye during the time-course and, at 48hrs floated over the heavy silicone oil, successfully changing the density of the tamponade.

Conclusions: : Our in vitro results suggest that it is possible to modify the tamponade density at any time point after vitreoretinal surgery by injecting a heavy agent into the vitreous cavity. This allows the surgeon to move the always present free space between the tamponade and the retina from the lower to the upper quadrant. This technique also enables the surgeon to obtain a more complete tamponade involving all parts of the retina, which might improve retinal stability and minimize recurrence of retinal detachment. The possibility to customize the tamponade might be very helpful to surgeons.Support: Florida Lions Eye Bank; Abeamed Inc; NIH Center Grant P30EY14801; Research to Prevent Blindness; Henri and Flore Lesieur Foundation (JMP).

Keywords: vitreoretinal surgery • retina • retinal detachment 
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