April 2009
Volume 50, Issue 13
Free
ARVO Annual Meeting Abstract  |   April 2009
The Effect of Transcorneal Stimulation in Cases of Central Retinal Artery Occlusion Using a New Waveform
Author Affiliations & Notes
  • M. J. Lopez
    Ophthalmology, Asociacion Para Evitar la Ceguera en Mexico, Mexico, Mexico
  • G. García-Aguirre
    Ophthalmology, Asociacion Para Evitar la Ceguera en Mexico, Mexico, Mexico
  • V. Morales-Canton
    Ophthalmology, Asociacion Para Evitar la Ceguera en Mexico, Mexico, Mexico
  • D. Robles Camarillo
    Sección de Estudios de Posgrado e Investigación ESIME-C, Instituto Politécnico Nacional, México City, Mexico, Mexico
  • L. Niño-de-Rivera y Oyarzabal PhD
    Sección de Estudios de Posgrado e Investigación ESIME-C, Instituto Politécnico Nacional, México City, Mexico, Mexico
  • H. Quiroz-Mercado
    Director of Ophthalmology Denver Health Medical Center and Professor of Ophthalmology School of Medicine University of Colorado, Denver, Colorado
  • Footnotes
    Commercial Relationships  M.J. Lopez, None; G. García-Aguirre, None; V. Morales-Canton, None; D. Robles Camarillo, None; L. Niño-de-Rivera y Oyarzabal PhD, None; H. Quiroz-Mercado, None.
  • Footnotes
    Support  None.
Investigative Ophthalmology & Visual Science April 2009, Vol.50, 128. doi:
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      M. J. Lopez, G. García-Aguirre, V. Morales-Canton, D. Robles Camarillo, L. Niño-de-Rivera y Oyarzabal PhD, H. Quiroz-Mercado; The Effect of Transcorneal Stimulation in Cases of Central Retinal Artery Occlusion Using a New Waveform. Invest. Ophthalmol. Vis. Sci. 2009;50(13):128.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: : The electrical stimulation of neural tissues seems to have a neuro-protective effect; this study describes the effect of Transcorneal Electrical Stimulation (TES) with a non conventional biphasic bipolar waveform in central retinal artery occlusion with onset of more than 3 months.

Methods: : In four patients 5 eyes were chosen with diagnosis of central artery occlusion (CRAO) and were treated with TES. Complete clinical evaluations, best corrected visual acuity (masked examination) and fluorescein angiography were performed. The TES was delivered by a monopolar contact lens electrode 3 times for 30 minutes every 3 weeks with a novel prototype system (10 minutes at 200mV/11.8 Hz, 10 minutes at 250mV/23.6Hz, and 10 minutes at 300mV/11.8Hz). The follow-up visits were at 1, 7, 15 days after stimulation; the clinical course was evaluated by BCVA, standardized electroretinogram and ophthalmic examination.

Results: : This waveform model induced phosphenes in patients with CRAO. Electroretinogram reported an increase in the b wave amplitude (p<0.05). BCVA increased in three of the eyes from 5/350 to 10/300; 10/600 to 10/225 and from light perception to hand movement, respectively.

Conclusions: : The phosphenes reported by the patients, and the visual acuity improvements suggest that the signal applied can stimulate retinal tissue and can increase retinal function. The registered response in this study is similar to previous reports.

Clinical Trial: : www.clinicaltrials.gov NCT00802698

Keywords: neuroprotection • electroretinography: clinical • visual acuity 
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