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K. Lim, S. Goyal, S. Rashid, L. Beltran-Agullo, R. Nath, S. Shah; Effect of Selective Laser Trabeculoplasty on Trabecular Outflow Facility and Intraocular Pressure. Invest. Ophthalmol. Vis. Sci. 2009;50(13):154.
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To investigate the effect of 180º & 360º Selective Laser Trabeculoplasy (SLT) treatment on intraocular pressure (IOP) & trabecular outflow facility (TOF).
One eye of untreated POAG (n=27) or OHT (n=10) patients (IOP 22-35 mmHg) was randomized to receive 180º (n=18) or 360º (n=19) SLT treatment. Fellow eyes of patients which did not require treatment were used as controls (n=8). TOF (electronic Schiotz tonography, C, µl/min/mm) and IOP (mmHg) were measured at pre & 1 month post SLT.
No significant changes in IOP & TOF were seen in the controlled eyes between baseline and one month. In 180º SLT group: IOP were reduced from 24.4 ± 4.1 (Mean ± SD) at baseline to 19.0 ± 5.2 at 1 month (p<0.001); while TOF were increase from 0.08 ± 0.04 to 0.11 ± 0.04 at 1 month (p=0.003). In the 360 º group: IOP were reduced from 24.4 ± 4.1 (Mean ± SD) at baseline to 19.0 ± 5.2 at 1 month (p<0.001); while TOF were increase from 0.08 ± 0.04 to 0.11 ± 0.04 at 1 month (p=0.005). However, the differences in IOP and TOF between the 180º and 360º groups were not statistically significant (p=0.35 & p=0.23 respectively). The SLT treatment caused overall reduction of 29% in IOP and 38% increased in TOF.
Both 180 º and 360º SLT treatment had greater effect on IOP and TOF. The overall reduction in IOP following SLT can not be explained by the increase in TOF alone.
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