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C. J. Gee, S. K. Kurup; Intravitreal Methotrexate in Therapeutically Resistant Exudative Age Related Macular Degeneration. Invest. Ophthalmol. Vis. Sci. 2009;50(13):228.
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To evaluate the therapeutic effect of intravitreal methotrexate in patients with exudative age related macular degeneration refractory to anti-VEGF (vascular endothelial growth factor) and corticosteroids.
Two male patients (Ages 74 and 89) with exudative age related macular degeneration were given 400 microgram per 0.1 cc intravitreal methotrexate (IV-MTX)
Resolution of subretinal fluid was observed in both patients demonstrated by ocular coherence tomography (OCT) at day 15.
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