April 2009
Volume 50, Issue 13
ARVO Annual Meeting Abstract  |   April 2009
Pattern Stimulated Visual Training With Mp-1 Microperimeter in Evoluted AMD Patients
Author Affiliations & Notes
  • E. M. Vingolo
    UOC Ophthalmology "S.M.Goretti" Hospital, University La Sapienza of Rome, Latina, Italy
  • S. Salvatore
    Ophthalmology, University La Sapienza of Rome, Rome, Italy
  • E. Perrotta
    Ophthalmology, University La Sapienza of Rome, Rome, Italy
  • F. Parisi
    Eye.Com Society, Rome, Italy
  • A. Palombi
    Ophthalmology, University La Sapienza of Rome, Rome, Italy
  • D. Domanico
    Ophthalmology, University La Sapienza of Rome, Rome, Italy
  • Footnotes
    Commercial Relationships  E.M. Vingolo, None; S. Salvatore, None; E. Perrotta, None; F. Parisi, None; A. Palombi, None; D. Domanico, None.
  • Footnotes
    Support  Uniroma1/C26F078TF3/2008
Investigative Ophthalmology & Visual Science April 2009, Vol.50, 233. doi:
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    • Get Citation

      E. M. Vingolo, S. Salvatore, E. Perrotta, F. Parisi, A. Palombi, D. Domanico; Pattern Stimulated Visual Training With Mp-1 Microperimeter in Evoluted AMD Patients. Invest. Ophthalmol. Vis. Sci. 2009;50(13):233.

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      © ARVO (1962-2015); The Authors (2016-present)

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Purpose: : analyze biofeedback training by microperimeter MP-1 (Nidek Technologies) on patients with Age Related Maculopathy (AMD)with pattern stimulation.

Methods: : We enrolled 15 patients (7 female and 8 male) mean age 72.21±;8,37 and examined total of 25 eyes with terminal wetAMD. All the patient underwent to a complete eye examination BCVA, reading speed, fixation stability and retinal sensitivity, 10 training sessions of 10 minutes for each eye, were performed once a week using the MP-1 biofeedback pattern stimulation (8 arcmin square). Statistical analysis was performed using Student's t-test on BCVA, Retinal Sensitivity and fixation stability. p values less than 0.05 were considered statistically significant.

Results: : All patients displayed an improvement in visual acuity (p=0.048), fixation behaviour (p=0.0012), retinal sensitivity (p=0.027) and reading speed (p=0,033). Mean character size value for near vision dramatically improved from 36.4 to 11.7; this result was statistically significant (p=0.031).

Conclusions: : A biofeedback pattern stimulation obtained using the MP-1 microperimeter can help the brain to exercise and stabilize a new PRL increasing attention modulation, providing, in patients with macular disease and central scotoma, more efficient preferred retinal locus and visual tasks. Patterned stimulation has highly significative recognition shapes that increase inner retina integration processes and optimize stimulus processing, recognition and brain transmission. Our group of AMD patients presented increased fixation stability demonstrating, according ours and others authors studies, that even in final stages of wet AMD there is a residual cerebral plasticity that can be used to partially restore sight. This result may be obtained overriding damaged photoreceptors improving integrative processes in outer and mainly in inner retina. Pattern stimulation was targeted on receptive fields highly sensitive mean spatial frequencies because such stimulus provides an higher informative content for ganglion cells than light alone as is used in IBIS stimulation (Contestabile et al 2003). Moreover MP-1 microperimetry assures high level of accuracy in fixation control by the mean of a more efficient eye-tracker system than steady state VEP (Vingolo et al 2008). Finally our results demonstrate that, after the anti-VEGF therapy, low vision patients still have a good chance to improve their quality of life with biofeedback and or light stimulation.

Keywords: age-related macular degeneration • low vision • neuro-ophthalmology: cortical function/rehabilitation 

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