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A. Takamiya, H. Kagokawa, D. Kameyama, S. Ishiko, A. Yoshida; Early Optical Coherence Tomography Examination After Photodynamic Therapy in Age-Related Macular Degeneration With Predominantly and Minimally Classic Choroidal Neovascularization. Invest. Ophthalmol. Vis. Sci. 2009;50(13):245.
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© ARVO (1962-2015); The Authors (2016-present)
To compare early changes in foveal thickness on optical coherence tomography (OCT) between predominantly and minimally classic choroidal neovascularization (CNV) in the early period after photodynamic therapy (PDT) in age-related macular degeneration (AMD).
Consecutive patients with AMD, who were treated with PDT for subfoveal CNV, were enrolled in this prospective comparative case series study. Ten eyes of 10 patients were divided into two groups; group A included eyes with predominantly classic CNV and group B included eyes with minimally classic or occult CNV. All eyes had undergone serial examinations with Fourier domain OCT (FD-OCT, RTvue-100TM) before PDT and 2, 12, and 36 hours and 1 month after PDT. The early OCT changes in the neuroretinal foveal thickness (NFT), bilaminar foveal thickness (BFT), and subretinal fluid (SRF) at the subfoveal lesion were measured after PDT.
FD-OCT showed a significant increase (P<0.05) in the BFT and SRF 2 hours after PDT compared to baseline that began to decrease 36 hours after PDT in both groups. There was no difference in the NFT and BFT at the foveal lesions between the groups before and after treatment. The SRF at the subfoveal lesions increased significantly (p<0.05) in group A eyes compared with group B eyes.
Early changes in the foveal lesions seen on FD-OCT indicate that PDT causes different retinal responses in predominantly classic versus minimally classic CNV.
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