April 2009
Volume 50, Issue 13
Free
ARVO Annual Meeting Abstract  |   April 2009
Can Infrared Spectrum Imaging Diagnose Polypoidal Choroidal Vasculopathy Without Indocyanine Green Angiography?
T. Agawa; Y. Yamauchi; T. Mizusawa; A. Nakamura; M. Nomura; Y. Ishii; S. Otsubo; K. Aizawa; T. Sota; H. Goto
Author Affiliations & Notes
  • T. Agawa
    Ophthalmology, Tokyo Medical University Hospital, Tokyo, Japan
  • Y. Yamauchi
    Ophthalmology, Tokyo Medical University Hospital, Tokyo, Japan
  • T. Mizusawa
    Ophthalmology, Tokyo Medical University Hospital, Tokyo, Japan
  • A. Nakamura
    Science and engineering, Waseda University, Tokyo, Japan
  • M. Nomura
    Science and engineering, Waseda University, Tokyo, Japan
  • Y. Ishii
    Science and engineering, Waseda University, Tokyo, Japan
  • S. Otsubo
    Science and engineering, Waseda University, Tokyo, Japan
  • K. Aizawa
    Science and engineering, Waseda University, Tokyo, Japan
  • T. Sota
    Science and engineering, Waseda University, Tokyo, Japan
  • H. Goto
    Ophthalmology, Tokyo Medical University Hospital, Tokyo, Japan
  • Footnotes
    Commercial Relationships  T. Agawa, None; Y. Yamauchi, None; T. Mizusawa, None; A. Nakamura, None; M. Nomura, None; Y. Ishii, None; S. Otsubo, None; K. Aizawa, None; T. Sota, None; H. Goto, None.
  • Footnotes
    Support  None.
Investigative Ophthalmology & Visual Science April 2009, Vol.50, 314. doi:
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      T. Agawa, Y. Yamauchi, T. Mizusawa, A. Nakamura, M. Nomura, Y. Ishii, S. Otsubo, K. Aizawa, T. Sota, H. Goto; Can Infrared Spectrum Imaging Diagnose Polypoidal Choroidal Vasculopathy Without Indocyanine Green Angiography?. Invest. Ophthalmol. Vis. Sci. 2009;50(13):314.

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Abstract

Purpose: : In a recent tend, optical coherence tomography plays an important role of clinical evaluation of polypoidal choroidal vasculopathy (PCV). However, indocyanine green angiography (IA) is still powerful tool to diagnose PCV especially at initial diagnosis. Nevertheless, IA requires a burden, intravenous injection. Thus, a new diagnostic method of PCV using infrared spectrum imaging (ISI) without intravenous injection was estimated in this study.

Methods: : Nine eyes of 9 patients suspected PCV clinically at initial attendance to Tokyo Medical University Hospital were included in this study. Color fundus photograph, IA and ISI was performed. The device of ISI, customized commercial fundus camera (VX-10i; Kowa, Nagoya), applied hyper spectrum (720-950 nm) imaging technology. The system allows 5 seconds to obtain the data of a 50-degree field at the surface. To create an image of blood speed in choroidal vessels, principal component of acquired spectral data was analyzed. Moving-average method of the image was hired to reduce the artifact. The light and shade in the spectrum imaging means the speed of circulation of the choroid. When speed of choroidal circulaton is high, domain is supposed to be depicted brightly. Spectrum image was superimposed on late phase IA image to estimate the capability of ISI to detect choroidal polyp.

Results: : In all of 9 patients, orange elevated lesion in color fundus photograph and hyper fluorescein of PCV in IA was identified. Blight domains in the style of PCV, depicted in ISI, accorded with hyper fluorescein of PCV in IA in 7 of 9 patients. However, in those 7 patients some of hyper fluorescein of PCV in IA was not depicted as blight domains in ISI.

Conclusions: : Even though ISI didn’t show identically same image in IA in patients with PCV at the present time, ISI is capable to diagnose PCV with primary version.

Keywords: age-related macular degeneration • imaging/image analysis: clinical 
© 2009, The Association for Research in Vision and Ophthalmology, Inc., all rights reserved. Permission to republish any abstract or part of an abstract in any form must be obtained in writing from the ARVO Office prior to publication.
Copyright © 2025 Association for Research in Vision and Ophthalmology.
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