Abstract
Purpose: :
to evaluate the effects of intravitreal antiangiogenic drugs on retrobulbar haemodynamics by color Doppler imaging (CDI) in patients with essudative age-related macular degeneration (AMD).
Methods: :
30 eyes of 30 patients with essudative AMD, 10 treated with Pegaptanib sodium, 10 with Ranibizumab and 10 with Bevacizumab were evaluated before and after intravitreal drug’s injection. 30 eyes of 30 healthy subjects were evaluated as control group.CDI was performed to measure peak systolic velocity, end diastolic velocity and resistive index of the ophthalmic artery, central retinal artery and posterior ciliary arteries. Maximum, minimum and mean velocities from central retinal vein and superior ophthalmic vein were also obtained by CDI.
Results: :
no significant differences were detected among preoperative and postoperative haemoynamics values in patients undergoing intravitreal drugs’ injections (p > 0,05). Besides, blood velocity Doppler parameters of orbital arteries and veins in patients with essudative AMD were similar to those of control group (p > 0,05).
Conclusions: :
this study demonstrates that intravitreal antiangiogenic drugs (Pegaptanib sodium, Ranibizumab and Bevacizumab) do not induce significant alteration on retrobulbar haemodynamics in patients with essudative AMD.
Keywords: drug toxicity/drug effects • imaging methods (CT, FA, ICG, MRI, OCT, RTA, SLO, ultrasound) • age-related macular degeneration