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L. Xu, Y. Wang, J. Wang, J. Jonas; Mortality and Ocular Diseases. The Beijing Eye Study. Invest. Ophthalmol. Vis. Sci. 2009;50(13):436.
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© ARVO (1962-2015); The Authors (2016-present)
To examine the relationship between mortality and major ocular diseases in a Population-based study
At baseline in 2001, the Beijing Eye Study examined 4439 subjects with an age of 40+ years. The mean age was 56.2±10.6 years (40-101 years). The participants underwent a detailed ophthalmic examination and answered questions on the socioeconomic background. In 2006, all study participants were re-invited for a follow-up examination. Rate of mortality was determined in the follow-up survey of 2006.
Out of the 4439 subjects examined in the 2001, 3251 (73.2%) subjects returned for the follow-up examination, while 143 (3.2%) subjects were dead and 1045 (23.5%) subjects were alive however did not agree to be re-examined. In binary logistic regression analysis, mortality was significantly associated with the systemic parameters of higher age (P<0.001; Odds ratio (OR):1.07), male gender (P=0.01;OR:0.55), lower level of education (P<0.001;OR:0.65), and smoking (P=0.023;OR:1.25), and with the ocular parameters of level of diabetic-like retinopathy (P=0.036;OR:1.02), presence of angle-closure glaucoma (P=0.013;OR:3.74), and presence of non-glaucomatous optic nerve damage (P=0.027;OR:3.41). Presence of retinal vein occlusions was marginally associated with mortality (P=0.059;OR=2.59). Mortality was not significantly associated with best corrected visual acuity (P=0.14) in multivariate analysis, nor with age-related macular degeneration, open-angle glaucoma, trachoma, any type of cataract, visual field defects, intraocular pressure and refractive error.
If socioeconomic parameters, age, gender and smoking were taken into account, ocular parameters associated with an increased mortality were diabetic-like retinopathy, angle-closure glaucoma, and non-glaucomatous optic nerve damage. Retinal vein occlusions were marginally associated. Other major ocular disorders such as any form of cataract, open-angle glaucoma, age-related macular degeneration, trachoma, pterygia, and high myopia or high hyperopia were not significantly related with mortality.
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