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F. Lerner, S. Basualdo, J. Lacassagne, L. Didionisio, C. Picotti, D. Scaricaciottoli; Screening of first-degree relatives of patients with Primary Open-Angle Glaucoma (POAG). Invest. Ophthalmol. Vis. Sci. 2009;50(13):437.
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Due to its low prevalence in the general population, screening for POAG may have a low predictive value of a positive test. Screening of high-risk groups may yield better results. If having a first-degree relative with glaucoma is a risk factor for developing the disease, a detection campaign focused in the relatives of glaucoma patients would have more probabilities of detection. The purpose of this study was to perform a glaucoma detection campaign among first-degree relatives of glaucoma patients. The results were compared with a control group of a detection campaign performed among patients attending the ophthalmology service of our institution for the first time.
First-degree relatives of patients with POAG were included. A control group of subjects older than 55 y/o was also screened. Subjects underwent a complete ophthalmic examination. Glaucoma was defined using the definition of the International Society for Geographical and Epidemiological Ophthalmology.
26.2% of 61 family members of 35 glaucoma patients, and 6% of 50 controls were diagnosed with glaucoma. Difference between groups was statistically significant (p =0.0052). Odds Ratio was 5.5 (IC 95%: 1.5-20.4).
Glaucoma detection was more effective when family members were screened when compared with the control group. In this study the probability of getting glaucoma with a family member affected was greater than the control group.
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