April 2009
Volume 50, Issue 13
Free
ARVO Annual Meeting Abstract  |   April 2009
Screening of first-degree relatives of patients with Primary Open-Angle Glaucoma (POAG)
Author Affiliations & Notes
  • F. Lerner
    Ophthalmology, Univ Favaloro, Buenos Aires, Argentina
    Hospital Malvinas Argentinas. Fundacion para el Estudio del Glaucoma, Buenos Aires, Argentina
  • S. Basualdo
    Ophthalmology, Hospital Malvinas Argentinas, Buenos Aires, Argentina
  • J. Lacassagne
    Ophthalmology, Hospital Malvinas Argentinas, Buenos Aires, Argentina
  • L. Didionisio
    Ophthalmology, Hospital Malvinas Argentinas, Buenos Aires, Argentina
  • C. Picotti
    Ophthalmology, Hospital Malvinas Argentinas, Buenos Aires, Argentina
  • D. Scaricaciottoli
    Ophthalmology, Hospital Malvinas Argentinas, Buenos Aires, Argentina
  • Footnotes
    Commercial Relationships  F. Lerner, None; S. Basualdo, None; J. Lacassagne, None; L. Didionisio, None; C. Picotti, None; D. Scaricaciottoli, None.
  • Footnotes
    Support  None.
Investigative Ophthalmology & Visual Science April 2009, Vol.50, 437. doi:
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    • Get Citation

      F. Lerner, S. Basualdo, J. Lacassagne, L. Didionisio, C. Picotti, D. Scaricaciottoli; Screening of first-degree relatives of patients with Primary Open-Angle Glaucoma (POAG). Invest. Ophthalmol. Vis. Sci. 2009;50(13):437.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: : Due to its low prevalence in the general population, screening for POAG may have a low predictive value of a positive test. Screening of high-risk groups may yield better results. If having a first-degree relative with glaucoma is a risk factor for developing the disease, a detection campaign focused in the relatives of glaucoma patients would have more probabilities of detection. The purpose of this study was to perform a glaucoma detection campaign among first-degree relatives of glaucoma patients. The results were compared with a control group of a detection campaign performed among patients attending the ophthalmology service of our institution for the first time.

Methods: : First-degree relatives of patients with POAG were included. A control group of subjects older than 55 y/o was also screened. Subjects underwent a complete ophthalmic examination. Glaucoma was defined using the definition of the International Society for Geographical and Epidemiological Ophthalmology.

Results: : 26.2% of 61 family members of 35 glaucoma patients, and 6% of 50 controls were diagnosed with glaucoma. Difference between groups was statistically significant (p =0.0052). Odds Ratio was 5.5 (IC 95%: 1.5-20.4).

Conclusions: : Glaucoma detection was more effective when family members were screened when compared with the control group. In this study the probability of getting glaucoma with a family member affected was greater than the control group.

Keywords: clinical (human) or epidemiologic studies: prevalence/incidence • detection • clinical (human) or epidemiologic studies: risk factor assessment 
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