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L. R. Vilela, P. N. Carneiro, V. N. Souza, D. V. Sampaio, R. C. Vilela, L. D. Carvalho, F. N. Kanadani, T. C. A. Moreira; Mitomycin C and Glaucoma - Time or Dose Dependent?. Invest. Ophthalmol. Vis. Sci. 2009;50(13):465.
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To evaluate the effects of subconjuntival infiltration of mitomycin C (MMC) in rabbits, comparing dose and time.
Mitomycin C was injected subconjuntivally in 148 rabbit eyes. There was a variation in dose [0,5mg/ml, 0,3mg/ml, 0,1mg/ml and 0,01 mg/ml] and time [days 0, 2 and 4]. We analyzed 22 parameters: corneal edema, corneal epithelial disruption, keratitis, Descemet's membrane thickening, pannus, angle synechiae, angle granuloma; iris neovascularization, necrosis, vasodilatation, inflammation, hemorrhage and granuloma; ciliary body vasodilatation; perilimbal vasodilatation, granuloma, inflammation, neovascularization, hemorrhage, stromal cell reduction, vessels disruption and characteristics of the epithelium.
Perilimbal hemorrhage, epithelial changes and inflammation are typically dose dependent. Corneal edema, perilimbal stromal cell reduction and perilimbal vascular disruption are mostly time dependent. Other changes, such as iris necrosis, inflammation and hemorrhage seem to be both time and dose dependent. There were intraocular damages when a higher dose of subconjutival MMC was injected.
The changes after MMC injection in rabbit eyes are both time and dose dependent. There is intraocular damage after subconjutival injection.
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