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P. Boey, W. Tay, E. Tai, P. Mitchell, J. Wang, S. Saw, T. Aung, T. Wong; C-Reactive Protein and Age-Related Cataract: The Singapore Malay Eye Study. Invest. Ophthalmol. Vis. Sci. 2009;50(13):500.
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© ARVO (1962-2015); The Authors (2016-present)
To describe the associations between C-reactive protein (CRP), a systemic marker of inflammation, and age-related cataract in an Asian population.
A population-based, cross-sectional study of 3,280 (78.7% response) Malay persons aged 40-80 years residing in Singapore was conducted in 2004-6. A digital slit-lamp camera (Topcon model DC-1; Topcon, Japan with FD-21 flash attachment) and a Scheimpflug retroillumination camera (Nidek EAS-1000, Nidek, Japan) were used to photograph the lens through dilated pupils for assessment of nuclear, cortical and posterior subcapsular (PSC) cataract using the Wisconsin cataract grading system. Non-fasting venous blood samples were taken from all participants and assessed for serum CRP levels.
CRP data were available for 2881 adults and of these, 1139 (39.5%) had cataract: 549 (19.1%), 836 (29.0%) and 400 (13.9%) had nuclear, cortical and PSC cataract, respectively. After adjusting for age and gender, CRP level was not significantly associated with the prevalence of any cataract (odds ratio [OR]: 1.06, 95% confidence interval [CI]: 0.82-1.37, 4th versus 1st quartile of CRP levels), nuclear (OR: 0.78, 95% CI: 0.56-1.07), cortical (OR: 1.02, 95% CI: 0.79-1.31), or posterior subcapsular (PSC) cataract (OR: 1.07, 95% CI 0.79-1.46). These associations did not change in analyses that also adjusted for diabetes, smoking, and other cataract risk factors. In sub-group analyses, among persons aged 60-69 years, higher CRP levels were associated with an increased risk of PSC cataract (OR 1.86, 95% CI 1.06-3.28). However, in those aged 70-80 years, higher CRP levels were associated with a decreased risk of PSC cataract (OR: 0.57, 95% CI 0.36-0.92).
No consistent association between C-reactive protein and age-related cataract were found in this Asian population. These data do not support systemic inflammation as a major risk factor for age-related cataract.
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