April 2009
Volume 50, Issue 13
Free
ARVO Annual Meeting Abstract  |   April 2009
Comparison of Visual Outcomes After Epithelial Laser-Assisted Keratomileusis (Epi-Lasik) and Photorefractive Keratectomy (PRK)
J. D. Edwards; K. S. Bower; D. A. Sediq; C. D. Coe; C. P. Kuzmowych; J. B. Eaddy; L. Peppers
Author Affiliations & Notes
  • J. D. Edwards
    Ophthalmology, Walter Reed Army Medical Center, Washington, Dist. of Columbia
  • K. S. Bower
    Ophthalmology, Walter Reed Army Medical Center, Washington, Dist. of Columbia
  • D. A. Sediq
    Ophthalmology, Walter Reed Army Medical Center, Washington, Dist. of Columbia
  • C. D. Coe
    Ophthalmology, Walter Reed Army Medical Center, Washington, Dist. of Columbia
  • C. P. Kuzmowych
    Ophthalmology, Walter Reed Army Medical Center, Washington, Dist. of Columbia
  • J. B. Eaddy
    Ophthalmology, Walter Reed Army Medical Center, Washington, Dist. of Columbia
  • L. Peppers
    Ophthalmology, Walter Reed Army Medical Center, Washington, Dist. of Columbia
  • Footnotes
    Commercial Relationships  J.D. Edwards, None; K.S. Bower, None; D.A. Sediq, None; C.D. Coe, None; C.P. Kuzmowych, None; J.B. Eaddy, None; L. Peppers, None.
  • Footnotes
    Support  None.
Investigative Ophthalmology & Visual Science April 2009, Vol.50, 553. doi:
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      J. D. Edwards, K. S. Bower, D. A. Sediq, C. D. Coe, C. P. Kuzmowych, J. B. Eaddy, L. Peppers; Comparison of Visual Outcomes After Epithelial Laser-Assisted Keratomileusis (Epi-Lasik) and Photorefractive Keratectomy (PRK). Invest. Ophthalmol. Vis. Sci. 2009;50(13):553.

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Abstract

Purpose: : To evaluate visual results following Epi-lasik compared to photorefractive keratectomy (PRK).

Methods: : Prospective study of 294 active duty US Army soldiers age 21 or over, who underwent Epi-lasik (298 eyes) or PRK (290 eyes) for low to moderate myopia or myopic astigmatism. Epi-lasik was performed with the Amadeus II epikeratome and PRK with the Amoils rotary epithelial brush. All ablations were performed using the LADARVision 6000 excimer laser system with emmetropia as the post-op target. Testing pre-op and at 1M, 3M, 6M and 12M post-op included uncorrected visual acuity (UCVA), manifest refraction, best spectacle-corrected visual acuity (BSCVA), 5% and 25% low contrast visual acuity (LCVA) and corneal haze. Statistical analysis was performed using SPSS software version 15.0 using either the Student T-test for normally distributed data or the Mann-Whitney test when there were several measured variables.

Results: : The mean age of Epi-lasik patients was 34.3±8.2 vs. 34.1±7.4 for PRK patients (p=0.807). The mean pre-op manifest spherical equivalent (MSE) was -2.97±1.19D (range -1.00 to -6.25) for Epi-lasik vs. -2.94±1.06D (-1.00 to -6.00) for PRK (p=0.819). Post-op UCVA met or exceeded pre-op BSCVA in 83.6% of Epi-lasik compared to 71.7% of PRK patients at 6M (p=0.027). UCVA of 20/15 or better was more likely following Epi-lasik compared to PRK at 1M (26.2% vs. 17.8%, p=0.032), 3M (63.5% vs. 49.3%, p=0.000), 6M (77.8% vs. 57.9%, p=0.000) and 12M (76.2% vs. 61.9%, p=0.001). LCVA (5 and 25%) was comparable between the treatment groups at all time points except 5% LCVA at 12M, which was unchanged or better than pre-op in 93.9% of Epi-lasik patients vs. 78.3% of PRK patients (p=0.000). There was no difference between the two procedures in BSCVA, predictability (MSE ±0.5 D or ±1.0D), or clinically significant corneal haze at any time point.

Clinical Trial: : www.clinicaltrials.gov NCT00413517

Keywords: refractive surgery: comparative studies • refractive surgery: optical quality • refractive surgery: PRK 
© 2009, The Association for Research in Vision and Ophthalmology, Inc., all rights reserved. Permission to republish any abstract or part of an abstract in any form must be obtained in writing from the ARVO Office prior to publication.
Copyright © 2025 Association for Research in Vision and Ophthalmology.
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