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A. Y. Li, S. Dutta, D. C. Musch, R. Shtein, S. I. Mian; Dry Eyes and Corneal Sensation After LASIK With the IntraLase® Femtosecond Laser: Effect of Hinge Position, Hinge Angle, and Flap Thickness. Invest. Ophthalmol. Vis. Sci. 2009;50(13):560.
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To determine if corneal sensation and dry eye syndrome after myopic LASIK surgery with IntraLase® are affected by varying hinge position, hinge angle, or flap thickness.Setting: University-based academic practice, Ann Arbor, Michigan, USA.
190 consecutive eyes of 95 patients were prospectively evaluated in a randomized contralateral-eye study after bilateral myopic LASIK with IntraLase® which compared: superior and temporal hinge position, 45º and 90º hinge angle, and 100 µm and 130 µm corneal flap thickness. Central Cochet-Bonnet esthesiometry, ocular surface disease index questionnaire, Schirmer with anesthesia, tear break-up time, corneal fluorescein and conjuctival lissamine green staining were evaluated pre-operatively as well as at 1 week and 1, 3, 6, and 12 months post-operatively.
Corneal sensation was reduced at all time points after LASIK with improvement over 12 months (p<0.001). There was no difference in corneal sensation between the different hinge positions, angles, or flap thicknesses at any time point. Overall ocular surface disease index score was increased at 1 week, 1 month, and 3 months postoperatively (p<0.0001, p<0.0001, p=0.046). Percentage of patients with tear break-up time greater than 10 seconds was significantly lower at 1 week and 1 month (p<0.0001), and mean corneal fluorescein staining was significantly higher at week 1 (p<0.0001) postoperatively. There was no difference in ocular surface index score, Schirmer with anesthesia, tear break-up time, lissamine green and fluorescein staining in contralateral eyes when comparing hinge position, hinge angle, and flap thickness.
Clinical Trial: :
www.clinicaltrials.gov HUM 18730-IDES
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