April 2009
Volume 50, Issue 13
Free
ARVO Annual Meeting Abstract  |   April 2009
Photorefractive Keratectomy (PRK) vs. Epi-lasik: Comparing Refractive Outcomes, Monochromatic Aberrations, and Optical Quality
C. D. Coe; K. S. Bower; J. D. Edwards; D. A. Sediq; B. C. Rimm; S. Molinar; L. Peppers
Author Affiliations & Notes
  • C. D. Coe
    Ophthalmology, Walter Reed Army Medical Center, Washington, Dist. of Columbia
  • K. S. Bower
    Ophthalmology, Walter Reed Army Medical Center, Washington, Dist. of Columbia
  • J. D. Edwards
    Ophthalmology, Walter Reed Army Medical Center, Washington, Dist. of Columbia
  • D. A. Sediq
    Ophthalmology, Walter Reed Army Medical Center, Washington, Dist. of Columbia
  • B. C. Rimm
    Ophthalmology, Walter Reed Army Medical Center, Washington, Dist. of Columbia
  • S. Molinar
    Ophthalmology, Walter Reed Army Medical Center, Washington, Dist. of Columbia
  • L. Peppers
    Ophthalmology, Walter Reed Army Medical Center, Washington, Dist. of Columbia
  • Footnotes
    Commercial Relationships  C.D. Coe, None; K.S. Bower, None; J.D. Edwards, None; D.A. Sediq, None; B.C. Rimm, None; S. Molinar, None; L. Peppers, None.
  • Footnotes
    Support  None.
Investigative Ophthalmology & Visual Science April 2009, Vol.50, 569. doi:
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      C. D. Coe, K. S. Bower, J. D. Edwards, D. A. Sediq, B. C. Rimm, S. Molinar, L. Peppers; Photorefractive Keratectomy (PRK) vs. Epi-lasik: Comparing Refractive Outcomes, Monochromatic Aberrations, and Optical Quality. Invest. Ophthalmol. Vis. Sci. 2009;50(13):569.

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Abstract

Purpose: : To compare the post-operative refractive outcomes, high order aberrations, and optical quality for two refractive surgery procedures.

Methods: : Prospective, non-randomized clinical trial comparing outcomes from photo-refractive keratectomy (PRK) (n=278) and Epi-lasik (n=165) utilizing an Alcon LADARVision 6000 laser utilizing conventional ablations. Epithelial flaps were generated using the Amadeus II microkeratome with epithelial separator (AMO Surgical, Irvine, California). Post-operative sphero-cylindrical refractions were converted into power vectors consisting of M (mean sphere), J0 (regular astigmatism), and J45 (oblique astigmatism). Monochromatic aberrations up to the 4th order were measured with a Shack-Hartmann wavefront analyzer. Total absolute higher order aberrations (HOA) RMS were also determined. Using Fourier optics and a subject’s wavefront, the area of a 2-D radially averaged MTF (normalized to dl-MTF) was calculated for 2 pupil sizes. Statistical analysis consisted of independent t- tests with an alpha of 0.05.

Results: : For M (Epi-lasik: M = +0.12;PRK: M=-0.04), J0 (Epi-lasik: M = +0.07;PRK: M=+0.03), and J45 (Epi-lasik:M=-0.011;PRK: M=+0.013), there were statistically significant differences across procedures. Total absolute HOA RMS did not significantly differ for either a 3mm pupil (Epi-lasik:M=0.098;PRK: M=0.092), or a 6mm pupil (Epi-lasik: M=0.88;PRK: M=0.80). The area underneath a normalized 2D-rMTF was almost identical across procedures and pupil diameter (3mm pupil (p=0.25) 6mm pupil (p=0.84)) and did not significantly differ.

Clinical Trial: : www.clinicaltrials.gov NCT00413517 and NCT00412568

Keywords: refractive surgery: optical quality 
© 2009, The Association for Research in Vision and Ophthalmology, Inc., all rights reserved. Permission to republish any abstract or part of an abstract in any form must be obtained in writing from the ARVO Office prior to publication.
Copyright © 2025 Association for Research in Vision and Ophthalmology.
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