April 2009
Volume 50, Issue 13
ARVO Annual Meeting Abstract  |   April 2009
Corneal Transplant Survival in Patients With Glaucoma
Author Affiliations & Notes
  • S. B. Kaye
    Ophthalmology, Royal Liverpool University Hospital, Liverpool, United Kingdom
  • R. K. Stewart
    Ophthalmology, Royal Liverpool University Hospital, Liverpool, United Kingdom
  • M. Jones
    Organ Donation and Transplantation, National Health Service Blood and Transplant, Bristol, United Kingdom
  • M. Batterbury
    Ophthalmology, Royal Liverpool University Hospital, Liverpool, United Kingdom
  • D. Tole
    Ophthalmology, University of Bristol, Bristol, United Kingdom
  • F. Larkin
    Ophthalmology, Moorfields Eye Hospital, London, United Kingdom
  • OTAG and Contributing Transplant Surgeons
    Ophthalmology, Royal Liverpool University Hospital, Liverpool, United Kingdom
  • Footnotes
    Commercial Relationships  S.B. Kaye, None; R.K. Stewart, None; M. Jones, None; M. Batterbury, None; D. Tole, None; F. Larkin, None.
  • Footnotes
    Support  None.
Investigative Ophthalmology & Visual Science April 2009, Vol.50, 623. doi:
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    • Get Citation

      S. B. Kaye, R. K. Stewart, M. Jones, M. Batterbury, D. Tole, F. Larkin, OTAG and Contributing Transplant Surgeons; Corneal Transplant Survival in Patients With Glaucoma. Invest. Ophthalmol. Vis. Sci. 2009;50(13):623.

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      © ARVO (1962-2015); The Authors (2016-present)

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Purpose: : To investigate corneal graft survival following penetrating keratoplasty in patients with glaucoma.

Methods: : All patients with glaucoma or who were on glaucoma medication that were registered with the United Kingdom, Organ Donation and Transplantation Service, undergoing their first penetrating keratoplasty (PK) during the period 1999 to 2006 were included. Patients were classified according to the indication for PK and similar cohorts of patients without glaucoma were included for comparison. Patient outcome data collected at surgery and at 1, 2 and 3years postoperatively included graft survival, visual acuity, rejection episodes, medications (including glaucoma medications) and surgical episodes (including glaucoma surgery). Further subgroup analyses were undertaken for those patients who underwent glaucoma surgery either before, at or following their PK.

Results: : 8249 patients, 1994 (F:M::49:51, age range:16-96 years) with and 6255 (F:M::47:53, age range:16-98 years) without glaucoma were included. Graft survival at 3 years was 72% (95% CI: 70-74) for those patients with glaucoma and 85% (95% CI: 85-87) for those without glaucoma (p <0.0001) (figure). Graft survival at 3years was 68% (95% CI: 45-83) for those patients who had pre-PK glaucoma surgery and 64% (95% CI:45-77) for those who underwent glaucoma surgery post-PK. Patients with glaucoma but not requiring pre or post-PK glaucoma surgery had a 3year graft survival of 73% (95% CI: 70-75)

Keywords: transplantation • cornea: endothelium • intraocular pressure 

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