April 2009
Volume 50, Issue 13
Free
ARVO Annual Meeting Abstract  |   April 2009
Correlation Between Right and Left Eyes in the Measurement of Retinal Vascular Fractal Dimension in an Older Population
V. Cosatto; A. Wainwright; E. Rochtchina; Y. P. Zhang; G. Liew; W. Hsu; M. L. Lee; P. Mitchell; T. Y. Wong; J. J. Wang
Author Affiliations & Notes
  • V. Cosatto
    Centre for Vision Research, Department of Ophthalmology and Westmead Millennium Institute, University of Sydney, Sydney, Australia
  • A. Wainwright
    Centre for Vision Research, Department of Ophthalmology and Westmead Millennium Institute, University of Sydney, Sydney, Australia
  • E. Rochtchina
    Centre for Vision Research, Department of Ophthalmology and Westmead Millennium Institute, University of Sydney, Sydney, Australia
  • Y. P. Zhang
    School of Electronic and Information Engineering, Ningbo University of Technology, Ningbo, China
  • G. Liew
    Centre for Vision Research, Department of Ophthalmology and Westmead Millennium Institute, University of Sydney, Sydney, Australia
  • W. Hsu
    School of Computing,
    National University of Singapore, Singapore, Singapore
  • M. L. Lee
    School of Computing,
    National University of Singapore, Singapore, Singapore
  • P. Mitchell
    Centre for Vision Research, Department of Ophthalmology and Westmead Millennium Institute, University of Sydney, Sydney, Australia
  • T. Y. Wong
    Singapore Eye Research Institute,
    National University of Singapore, Singapore, Singapore
    Centre for Eye Research Australia, University of Melbourne, Melbourne, Australia
  • J. J. Wang
    Centre for Vision Research, Department of Ophthalmology and Westmead Millennium Institute, University of Sydney, Sydney, Australia
    Centre for Eye Research Australia, University of Melbourne, Melbourne, Australia
  • Footnotes
    Commercial Relationships  V. Cosatto, None; A. Wainwright, None; E. Rochtchina, None; Y.P. Zhang, None; G. Liew, None; W. Hsu, None; M.L. Lee, None; P. Mitchell, None; T.Y. Wong, None; J.J. Wang, None.
  • Footnotes
    Support  Australian NHMRC grant nos. 153948, 211069, 302068; Pfizer and DART
Investigative Ophthalmology & Visual Science April 2009, Vol.50, 99. doi:
  • Views
  • Share
  • Tools
    • Alerts
      User Alerts
      You are adding an alert for:
      Correlation Between Right and Left Eyes in the Measurement of Retinal Vascular Fractal Dimension in an Older Population
      You will receive an email whenever this article is corrected, updated, or cited in the literature. You can manage this and all other alerts in My Account
      The alert will be sent to:
      ×
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation
      Citation

      V. Cosatto, A. Wainwright, E. Rochtchina, Y. P. Zhang, G. Liew, W. Hsu, M. L. Lee, P. Mitchell, T. Y. Wong, J. J. Wang; Correlation Between Right and Left Eyes in the Measurement of Retinal Vascular Fractal Dimension in an Older Population. Invest. Ophthalmol. Vis. Sci. 2009;50(13):99.

      Download citation file:

      © ARVO (1962-2015); The Authors (2016-present)

      ×
    • Get Permissions
  • Supplements
Abstract

Purpose: : Retinal vessel fractal dimension (Df) is a global measure of density in the retinal vasculature. Recent research suggests that this measurement may indicate subtle retinal microvascular changes associated with different ocular and systemic conditions. We assessed the correlation between Df measurements of the left and right eyes of the same person, using Blue Mountains Eye Study (BMES) data.

Methods: : A random subsample of 300 participants (600 eyes) was selected from the baseline BMES survey (1992-4). IRIS-Fractal (version 1.4) was used to measure Df, by outlining a skeletonised line tracing of the retinal vascular network from the original digitised image. Intraclass correlation coefficients (ICC) were used to assess intergrader reproducibility between graders on 300 right eye images. The mean Df of right and left eyes was compared using Student’s paired t-test, and the similarity in Df between right and left eyes was assessed using Pearson correlation coefficients (r).

Results: : In this subsample, 63% were female and the mean (SD) age was 63.8 (8.4) years. Intergrader reliability was high (ICC 0.90; 95% confidence interval, CI, 0.88-0.92). There was no significant difference in Df between right (mean 1.449 ± 0.018 SD) and left (1.450 ± 0.017) eyes (p=0.40). The correlation of Df between right and left eyes was moderate when graded by the same grader (r= 0.56; p< 0001) or by two different graders (r=0.55; p<0.0001). Age did not affect the right and left correlation of Df as the correlation was similar between persons aged <65 years (r=0.50) and those aged ≥65 years (r=0.55).

Keywords: clinical (human) or epidemiologic studies: systems/equipment/techniques • retina 
© 2009, The Association for Research in Vision and Ophthalmology, Inc., all rights reserved. Permission to republish any abstract or part of an abstract in any form must be obtained in writing from the ARVO Office prior to publication.
Copyright © 2025 Association for Research in Vision and Ophthalmology.
×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×
This site uses cookies. By continuing to use our website, you are agreeing to our privacy policy.Accept