April 2009
Volume 50, Issue 13
ARVO Annual Meeting Abstract  |   April 2009
A Clinical Adaptive Optics System
Author Affiliations & Notes
  • D. Gray
    Optos plc, Dunfermline, United Kingdom
  • B. Wall
    Optos plc, Dunfermline, United Kingdom
  • C. Robertson
    Optos plc, Dunfermline, United Kingdom
  • D. Cairns
    Optos plc, Dunfermline, United Kingdom
  • Footnotes
    Commercial Relationships  D. Gray, Optos plc, E; B. Wall, Optos plc, E; C. Robertson, Optos plc, E; D. Cairns, Optos plc, E.
  • Footnotes
    Support  None.
Investigative Ophthalmology & Visual Science April 2009, Vol.50, 1061. doi:
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    • Get Citation

      D. Gray, B. Wall, C. Robertson, D. Cairns; A Clinical Adaptive Optics System. Invest. Ophthalmol. Vis. Sci. 2009;50(13):1061.

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      © ARVO (1962-2015); The Authors (2016-present)

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Purpose: : A compact widefield adaptive optics (AO) retinal imaging system has been developed to be easy to use and suitable for routine clinical applications. Several imaging modalities are supported providing a broad range of applications.

Methods: : The imaging system consists of a flexible scan system coupled to a wide field-of-view optical relay, an eye aberration measurement and correction module, and a patient alignment system (PAS) incorporating three-dimensional pupil localization and a fixation target, and a laser and detector module supporting several imaging modalities. The flexible scan system supports an imaging protocol to enable the operator to navigate to pre-selected regions of interest and capture high-resolution retinal images as well as wide-field montages. The PAS system continuously monitors eye location and fixation stability, reporting optimal retinal imaging conditions. All sub-systems including PAS, AO, scanning, and image acquisition are in continuous communication. This permits automation of many functions to relieve the burden on the operator.

Results: : 10 degree (wide field) and 2.5 degrees (narrow field) retinal images have been acquired on a range of eyes of varying age, refractive error, and pathology. Post-registration and removal of warped frames of sequential, AO corrected, narrow field images have increased signal to noise, revealing a complete cone mosaic. Narrow field images have been registered to wide field images. In turn, these have been registered to ultra-widefield images acquired with Optos standard P200MA imaging systems.

Conclusions: : It is clear that practical clinical systems require excellent human factors. This work demonstrates any easy to use AO retinal imaging system designed for that challenge. It combines AO with a flexible scan system, PAS, modular control architecture, and integration with widefield imaging systems. Further work is required for full validation of performance in different clinical settings.

Keywords: imaging methods (CT, FA, ICG, MRI, OCT, RTA, SLO, ultrasound) • retina • photoreceptors 

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