Purchase this article with an account.
C. Y. Kim, S. Hong, G. Seong; Comparison of Peripapillary Retinal Nerve Fiber Layer Thickness Measured by Spectral vs. Time Domain Optical Coherence Tomography. Invest. Ophthalmol. Vis. Sci. 2009;50(13):1071.
Download citation file:
© ARVO (1962-2015); The Authors (2016-present)
To compare the peripapillary retinal nerve fiber layer (RNFL) thickness measured by spectral and time domain optical coherence tomography (OCT).
One hundred eighty-eight glaucoma and healthy subjects were included to study. Peripapillary RNFL thickness were measured by Optic Disc Cube 200 x 200 scan of spectral domain Cirrus HD OCT and by Fast RNFL scan of time domain Stratus OCT. Their associations and agreements were evaluated using linear regression (R2), Bland-Altman plot, and weighted Kappa (Kw) coefficient. Areas under the receiver operating characteristic curve (AROC) were also compared.
Except inferior quadrant, RNFL thickness measurements by Cirrus HD OCT were thinner than Stratus OCT. For inferior quadrant, this tendency was vice versa. Overall, the average RNFL thickness analyses of two OCTs showed good association (R2, 0.782) and agreement (mean of difference, 4.8 µm; Kw, 0.598). Regarding the AROC, both OCTs had the largest values for the average RNFL thickness (p=0.456).
Except inferior quadrant, the average and quadrants RNFL thickness measured by Cirrus HD OCT were thinner than Stratus OCT. The peripapillary RNFL thickness measurements and the probability codes of two OCTs showed good association and agreement. And they had almost similar discriminating powers of glaucoma detection.
Clinical Trial: :
This PDF is available to Subscribers Only