April 2009
Volume 50, Issue 13
Free
ARVO Annual Meeting Abstract  |   April 2009
High Resolution, Non-Invasive Spectral Domain OCT Imaging of Retinal and Optic Nerve Head Disease; A Case Series Illustrating Potential and Limitations
O. Puzyeyeva; J. Flanagan; W.-C. Lam; G. Trope; M. Brent; Y. M. Buys; M. Mandelcorn; R. Devenyi; C. Hudson
Author Affiliations & Notes
  • O. Puzyeyeva
    Institute of Medical Science,
    University of Toronto, Toronto, Ontario, Canada
    Department of Ophthalmology and Vision Science, Toronto Western Hospital, Toronto, Ontario, Canada
  • J. Flanagan
    Department of Ophthalmology and Vision Science,
    University of Toronto, Toronto, Ontario, Canada
    School of Optometry, University of Waterloo, Waterloo, Ontario, Canada
  • W.-C. Lam
    Department of Ophthalmology and Vision Science, Toronto Western Hospital, Toronto, Ontario, Canada
  • G. Trope
    Department of Ophthalmology and Vision Science, Toronto Western Hospital, Toronto, Ontario, Canada
  • M. Brent
    Department of Ophthalmology and Vision Science, Toronto Western Hospital, Toronto, Ontario, Canada
  • Y. M. Buys
    Department of Ophthalmology and Vision Science, Toronto Western Hospital, Toronto, Ontario, Canada
  • M. Mandelcorn
    Department of Ophthalmology and Vision Science, Toronto Western Hospital, Toronto, Ontario, Canada
  • R. Devenyi
    Department of Ophthalmology and Vision Science, Toronto Western Hospital, Toronto, Ontario, Canada
  • C. Hudson
    Department Ophthalmology and Vision Science,
    University of Toronto, Toronto, Ontario, Canada
    School of Optometry, University of Waterloo, Waterloo, Ontario, Canada
  • Footnotes
    Commercial Relationships  O. Puzyeyeva, None; J. Flanagan, None; W.-C. Lam, None; G. Trope, None; M. Brent, None; Y.M. Buys, None; M. Mandelcorn, None; R. Devenyi, None; C. Hudson, None.
  • Footnotes
    Support  AHS, CIHR
Investigative Ophthalmology & Visual Science April 2009, Vol.50, 1082. doi:
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      O. Puzyeyeva, J. Flanagan, W.-C. Lam, G. Trope, M. Brent, Y. M. Buys, M. Mandelcorn, R. Devenyi, C. Hudson; High Resolution, Non-Invasive Spectral Domain OCT Imaging of Retinal and Optic Nerve Head Disease; A Case Series Illustrating Potential and Limitations. Invest. Ophthalmol. Vis. Sci. 2009;50(13):1082.

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Abstract

Purpose: : To report a series of patients with retinal and optic nerve head disease who were imaged by spectral domain optical coherence tomography (SD-OCT) in order to illustrate the potential and limitations of this new imaging modality.

Methods: : The sample comprised 20 patients; four cases with age-related macular degeneration (ARMD); seven cases with diabetic retinopathy (DR); four cases with primary open angle glaucoma (POAG) ; two optic pit cases; and one case each of central artery occlusion, central vein occlusion, and branch retinal vein occlusion. Patients were imaged using Heidelberg Spectralis HRA + OCT (Heidelberg Engineering, Heidelberg, Germany) using the SD-OCT mode, a scan field of 30 degrees horizontally on 15 degrees vertically and 19 OCT horizontal sections (one section every 240µm). Patients also underwent digital fundus photography and clinical assessment.

Results: : SD-OCT of a case of age-related macular degeneration revealed a subfoveal choroidal neovascular membrane with retinal pigment epithelium (RPE) and neurosensory retina detachment with apparent thickening and wrinkling of a Bruch’s membrane and the RPE. A case of diabetic retinopathy and a case of branch retinal vein occlusion both displayed a cystoid pattern of macular edema with cystoid spaces visible in the outer retina. Cases of diabetic retinopathy undergoing laser treatment showed localized loss of RPE and inner retinal swelling post-laser. A case of POAG showed structural changes to ONH and peripapillary retina following reduction in IOP. Hyper-reflective lesions, such as hemorrhages, exudates, and major retinal vessels resulted in shadowing of the underlying retina. Automated segmentation of the retina sometimes requires manual adjustment prior to analysis.

Conclusions: : SD-OCT demonstrated patho-physiological detail of retinal and optic nerve head diseases that are not visible using clinical techniques. However, SD-OCT images need to be carefully evaluated to exclude the influence of artifacts.

Keywords: imaging/image analysis: clinical • retina • optic nerve 
© 2009, The Association for Research in Vision and Ophthalmology, Inc., all rights reserved. Permission to republish any abstract or part of an abstract in any form must be obtained in writing from the ARVO Office prior to publication.
Copyright © 2025 Association for Research in Vision and Ophthalmology.
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