April 2009
Volume 50, Issue 13
Free
ARVO Annual Meeting Abstract  |   April 2009
Reproducibility of Spectral-Domain Optical Coherence Tomography (SD-OCT) Measurements
A. I. Kim; K. A. Townsend; J. Baird; G. Wollstein; R. A. Bilonick; H. Ishikawa; L. Kagemann; J. S. Duker; J. G. Fujimoto; J. S. Schuman
Author Affiliations & Notes
  • A. I. Kim
    UPMC Eye Center, Eye & Ear Institute, Ophthalmology and Visual Science Research Center, Dept. Ophthalmology, U. Pittsburgh School of Medicine, Pittsburgh, Pennsylvania
  • K. A. Townsend
    UPMC Eye Center, Eye & Ear Institute, Ophthalmology and Visual Science Research Center, Dept. Ophthalmology, U. Pittsburgh School of Medicine, Pittsburgh, Pennsylvania
  • J. Baird
    UPMC Eye Center, Eye & Ear Institute, Ophthalmology and Visual Science Research Center, Dept. Ophthalmology, U. Pittsburgh School of Medicine, Pittsburgh, Pennsylvania
    Dept. Biostatistics, Graduate School of Public Health, U. Pittsburgh, Pittsburgh, Pennsylvania
  • G. Wollstein
    UPMC Eye Center, Eye & Ear Institute, Ophthalmology and Visual Science Research Center, Dept. Ophthalmology, U. Pittsburgh School of Medicine, Pittsburgh, Pennsylvania
  • R. A. Bilonick
    UPMC Eye Center, Eye & Ear Institute, Ophthalmology and Visual Science Research Center, Dept. Ophthalmology, U. Pittsburgh School of Medicine, Pittsburgh, Pennsylvania
  • H. Ishikawa
    UPMC Eye Center, Eye & Ear Institute, Ophthalmology and Visual Science Research Center, Dept. Ophthalmology, U. Pittsburgh School of Medicine, Pittsburgh, Pennsylvania
    Dept. Bioengineering, Swanson School of Engineering, U. Pittsburgh, Pittsburgh, Pennsylvania
  • L. Kagemann
    UPMC Eye Center, Eye & Ear Institute, Ophthalmology and Visual Science Research Center, Dept. Ophthalmology, U. Pittsburgh School of Medicine, Pittsburgh, Pennsylvania
    Dept. Bioengineering, Swanson School of Engineering, U. Pittsburgh, Pittsburgh, Pennsylvania
  • J. S. Duker
    New England Eye Center, Tufts Medical Center, Boston, Massachusetts
  • J. G. Fujimoto
    Dept. of Electrical Engineering and Computer Science and Research Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, Massachusetts
  • J. S. Schuman
    UPMC Eye Center, Eye & Ear Institute, Ophthalmology and Visual Science Research Center, Dept. Ophthalmology, U. Pittsburgh School of Medicine, Pittsburgh, Pennsylvania
    Dept. Bioengineering, Swanson School of Engineering, U. Pittsburgh, Pittsburgh, Pennsylvania
  • Footnotes
    Commercial Relationships  A.I. Kim, None; K.A. Townsend, None; J. Baird, None; G. Wollstein, Bioptigen, P; Carl Zeiss Meditec, F; Optovue, F; R.A. Bilonick, None; H. Ishikawa, Bioptigen, P; L. Kagemann, None; J.S. Duker, Zeiss, F; Optovue, F; Heidelberg, F; Alcon, C; Genentech, C; Paloma Pharmaceuticals, C; J.G. Fujimoto, Optovue, I; Carl Zeiss Meditec, P; J.S. Schuman, Carl Zeiss Meditec, P; Bioptigen, P; Alcon, R; Allergan, R; Carl Zeiss Meditec, R; Heidelberg Engineering, R; Merck, R; Lumenis, R; Optovue, R; Pfizer, R.
  • Footnotes
    Support  NIH R01-EY013178-9, R01-EY011289-23, P30-EY008098; AFOSR FA9550-040-1-0011; NSF BES-0522845; Eye and Ear Foundation (Pittsburgh, PA); Research to Prevent Blindness
Investigative Ophthalmology & Visual Science April 2009, Vol.50, 1086. doi:
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      A. I. Kim, K. A. Townsend, J. Baird, G. Wollstein, R. A. Bilonick, H. Ishikawa, L. Kagemann, J. S. Duker, J. G. Fujimoto, J. S. Schuman; Reproducibility of Spectral-Domain Optical Coherence Tomography (SD-OCT) Measurements. Invest. Ophthalmol. Vis. Sci. 2009;50(13):1086.

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Abstract

Purpose: : We previously reported the reproducibility of SD-OCT (RTVue, Optovue, Fremont, CA) using an early commercial version of the segmentation software. In this study we examine the effect of a software revision on reproducibility of retinal nerve fiber layer (RNFL) and foveal thickness measurements, and cup to disc ratio.

Methods: : Fifteen healthy subjects (16 eyes) and 12 glaucoma subjects (17 eyes) were scanned with time-domain OCT (TD-OCT; Stratus OCT, Carl Zeiss Meditec, Dublin, CA) using the fast RNFL, fast macula and fast optic disc scans, and with RTVue (software version 3.0) using the NHM4, RNFL 3.45 mm, and MM5 scans. All subjects had 3 qualified scans from each device in each of 3 (healthy) or 2 visits (glaucoma) within 2 months. Mixed effect models were used to calculate intravisit reproducibility as standard deviation (SD) and intraclass correlation coefficients (ICC).

Results: : RTVue RNFL measurements reported in the table were obtained from NHM4 scan. Using the RNFL 3.45 scan, the SD was 2.562 µm. RTVue had statistically significantly better reproducibility than Stratus in all parameters except for the overall fovea.

Conclusions: : Software modification can markedly improve the reproducibility of SD-OCT up to a level where it exceeds the reproducibility of TD-OCT.

Clinical Trial: : www.clinicaltrials.gov NCT00343746

Keywords: imaging methods (CT, FA, ICG, MRI, OCT, RTA, SLO, ultrasound) • nerve fiber layer • optic disc 
© 2009, The Association for Research in Vision and Ophthalmology, Inc., all rights reserved. Permission to republish any abstract or part of an abstract in any form must be obtained in writing from the ARVO Office prior to publication.
Copyright © 2025 Association for Research in Vision and Ophthalmology.
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