April 2009
Volume 50, Issue 13
Free
ARVO Annual Meeting Abstract  |   April 2009
Volumetric and Thickness Analysis of the Retina and Outer Nuclear Layer Using Spectral / Fourier Domain Optical Coherence Tomography in Normal and Non-Neovascular Age-Related Macular Degeneration Patients
V. Chaturvedi; N. Nandakumar; J. Ho; J. Lui; J. G. Fujimoto; J. S. Schuman; J. S. Duker; Y. Lui
Author Affiliations & Notes
  • V. Chaturvedi
    Ophthalmology, New England Eye Center, Boston, Massachusetts
  • N. Nandakumar
    Ophthalmology, New England Eye Center, Boston, Massachusetts
  • J. Ho
    Ophthalmology, New England Eye Center, Boston, Massachusetts
    Boston University School of Medicine, Boston, Massachusetts
  • J. Lui
    Department of Electrical Engineering and Computer Science and Research Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, Massachusetts
  • J. G. Fujimoto
    Department of Electrical Engineering and Computer Science and Research Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, Massachusetts
  • J. S. Schuman
    Eye and Ear Institute, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania
  • J. S. Duker
    Ophthalmology, New England Eye Center, Boston, Massachusetts
  • Y. Lui
    Department of Electrical Engineering and Computer Science and Research Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, Massachusetts
  • Footnotes
    Commercial Relationships  V. Chaturvedi, None; N. Nandakumar, None; J. Ho, for work on Optovue RTVue OCT Primer: Retina, R, R; J. Lui, None; J.G. Fujimoto, stock options in Optovue, Inc, I; receives royalties from intellectual property owned by MIT and licensed to Carl Zeiss Meditech, Inc., P; J.S. Schuman, receives research support and royalties from intellectual property licensed to Carl Zeiss Meditech, Inc, F; J.S. Duker, receives research support from Carl Zeiss Meditech, Inc., Optovue, Inc., and Topcon Medical Systems, Inc., F; Y. Lui, None.
  • Footnotes
    Support  Research to Prevent Blindness Challenge grant to the New England Eye Center, NIH RO1-EY11289-23, R01-EY13178-07, P30-EY008098, FA9550-07-1-0101, FA9550-07-1-0014.
Investigative Ophthalmology & Visual Science April 2009, Vol.50, 1091. doi:
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      V. Chaturvedi, N. Nandakumar, J. Ho, J. Lui, J. G. Fujimoto, J. S. Schuman, J. S. Duker, Y. Lui; Volumetric and Thickness Analysis of the Retina and Outer Nuclear Layer Using Spectral / Fourier Domain Optical Coherence Tomography in Normal and Non-Neovascular Age-Related Macular Degeneration Patients. Invest. Ophthalmol. Vis. Sci. 2009;50(13):1091.

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Abstract

Purpose: : To conduct retinal and Outer Nuclear Layer (ONL) volumetric and average thickness analysis in normal and dry Age-Related Macular Degeneration (ARMD) eyes.

Methods: : Six dry ARMD and 6 normal eyes (average age 67) were in our study. Study eyes did not have neovascular changes, ocular injection/surgery/laser (excluding cataract), other macular diagnoses, or spherical equivalent outside +5.00 to -6.00 diopters. Visual acuity, AREDS class (AREDS: design implications, Control Clin Trials, 1999), and Cirrus HD-OCT (Carl Zeiss Meditec, Dublin, CA) with macular cube 512x128 were noted. ONL measurements were done after remapping lines to the external limiting membrane and outer plexiform layers for each frame. Drusen area was calculated using "Slab view" (2D plane). Volume and thickness were plotted against acuity, AREDS class and drusen count/area.

Results: : ONL thickness was greatest at the central foveal region in normals (90±14 µm) and dry ARMD eyes (84±21 µm). Normal eyes had larger ONL/total retinal volume and average retinal/ONL thickness, compared to dry ARMD eyes (not statistically significant). Average ONL thickness had a negative correlation with drusen count (R2= 0.657) and drusen area (R2= 0.553). ONL volume was negatively correlated with drusen count (R2= 0.593) and drusen area (R2= 0.532). Average retinal and ONL thickness both had positive correlations with total retinal volume with R2= 0.991 and 0.975, respectively. Drusen area had high correlation with AREDS class (R2= 0.854).

Conclusions: : This is the first study that measured ONL volume in normal and dry ARMD eyes. ONL volumes were not significantly different in normal compared to dry ARMD eyes. Drusen area was a novel approach to analyze drusen and it correlated well to AREDS classification.

Keywords: age-related macular degeneration • imaging methods (CT, FA, ICG, MRI, OCT, RTA, SLO, ultrasound) • imaging/image analysis: clinical 
© 2009, The Association for Research in Vision and Ophthalmology, Inc., all rights reserved. Permission to republish any abstract or part of an abstract in any form must be obtained in writing from the ARVO Office prior to publication.
Copyright © 2025 Association for Research in Vision and Ophthalmology.
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