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B. Giambene, G. Virgili, U. Menchini; Retinal Nerve Fiber Layer Thickness in Optic Neuropathies and Normals: Reliability and Agreement Using Cirrus and Stratus Optical Coherence Tomography. Invest. Ophthalmol. Vis. Sci. 2009;50(13):1093.
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to evaluate the repeatability of retinal nerve fiber layer (RNFL) thickness measurements with Cirrus and Stratus optical coherence tomography (OCT) and the agreement between the two instruments in optic neuropathies and normals.
forty-five eyes with optic neuropathies (twenty-one post optic neuritis, twenty-four post anterior ischaemic optic neuropathy) and fifty normal eyes were studied. Average RNFL thickness was measured using Cirrus and Stratus OCTs. 95% limits of agreement and intraclass correlation coefficient (ICC) were determined.
95% limits of agreement and ICC for each instrument in the two groups of examined subjects were listed in table 1. Average RNFL thickness difference ±95% limits of agreement and ICC between Stratus and Cirrus OCTs were shown in table 2.
both instruments are reliable for RNFL thickness measurements in eyes with optic neuropathies and normal ones, but Cirrus OCT displays higher repeatability than Stratus OCT. Absolute RNFL thickness measures differ between the two devices, therefore they can be trustworthy used in clinical practice, but have not to be considered interchangeable.
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