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P. Panda, Z. Li, R. B. Nussenblatt; Pathway Specific Gene Expression Profiling in a Laser-induced Choroidal Neovascularization (cnv) Mouse Model. Invest. Ophthalmol. Vis. Sci. 2009;50(13):1169.
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A strong correlation of inflammatory responses in age-related macular degeneration (AMD) and choroidal neovascularization (CNV) has been well documented. The laser-induced CNV mouse model has been widely used to study molecular mechanisms and potential therapeutic targets for the treatment of AMD and CNV. This study aims to profile early inflammatory gene expression in murine eyes with laser-induced CNV.
Housekeeping genes such as GAPDH and internal positive controls were most strongly expressed in the control group. Complement C2 (an integral part of the complement cascade), glomulin (Glmn, an FKBP associated protein involved in vascular development), and bone morphogenetic protein 6 (BMP6, involved in collagen metabolism) were found up-regulated in the 24 hour laser group.
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