April 2009
Volume 50, Issue 13
Free
ARVO Annual Meeting Abstract  |   April 2009
Id1 Deficiency Suppresses Ocular Neovascularization
B. Xie; A. Dong; J. Shen; L. Lu; A. Rashid; T. YOSHIDA; S. Hackett; P. Campochiaro
Author Affiliations & Notes
  • B. Xie
    Ophthalmology, Shanghai Ruijin Hospital, Shanghai, China
    Wilmer Eye Institute, Johns Hopkins University, Baltimore, Maryland
  • A. Dong
    Wilmer Eye Institute, Johns Hopkins University, Baltimore, Maryland
  • J. Shen
    Wilmer Eye Institute, Johns Hopkins University, Baltimore, Maryland
  • L. Lu
    Wilmer Eye Institute, Johns Hopkins University, Baltimore, Maryland
  • A. Rashid
    Wilmer Eye Institute, Johns Hopkins University, Baltimore, Maryland
  • T. YOSHIDA
    Wilmer Eye Institute, Johns Hopkins University, Baltimore, Maryland
  • S. Hackett
    Wilmer Eye Institute, Johns Hopkins University, Baltimore, Maryland
  • P. Campochiaro
    Wilmer Eye Institute, Johns Hopkins University, Baltimore, Maryland
  • Footnotes
    Commercial Relationships  B. Xie, None; A. Dong, None; J. Shen, None; L. Lu, None; A. Rashid, None; T. Yoshida, None; S. Hackett, None; P. Campochiaro, None.
  • Footnotes
    Support  NIH Grant EY012609 and core grant P30EY1765 from the NEI
Investigative Ophthalmology & Visual Science April 2009, Vol.50, 1179. doi:
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      B. Xie, A. Dong, J. Shen, L. Lu, A. Rashid, T. YOSHIDA, S. Hackett, P. Campochiaro; Id1 Deficiency Suppresses Ocular Neovascularization. Invest. Ophthalmol. Vis. Sci. 2009;50(13):1179.

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Abstract

Purpose: : Inhibitor of differentiation (Id) proteins are dominant-negative helix-loop-helix (HLH) transcription factors primarily involved in regulating cellular differentiation. They have been implicated in tumor angiogenesis and in this study their affects in ocular neovascularization (NV) was investigated..

Methods: : Expression of Id1 was investigated in mice with ischemic retinopathy and transgenic mice with expression of VEGF in photoreceptors. Mice deficient in Id1 were used to test the effect of Id1 in retinal and choroidal NV.

Results: : Mice deficient in Id1 showed a significant reduction in ischemia-induced retinal NV, choroidal NV at rupture sites in Bruch’s membrane, and VEGF-induced subretinal neovascularization. Mice lacking Id1 showed reduced levels of hypoxia-inducible factor-1alpha (HIF-1alpha) and suppression of ischemia-induced expression of VEGF and VEGF receptor 1.

Keywords: age-related macular degeneration • neovascularization • gene/expression 
© 2009, The Association for Research in Vision and Ophthalmology, Inc., all rights reserved. Permission to republish any abstract or part of an abstract in any form must be obtained in writing from the ARVO Office prior to publication.
Copyright © 2025 Association for Research in Vision and Ophthalmology.
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