April 2009
Volume 50, Issue 13
Free
ARVO Annual Meeting Abstract  |   April 2009
Effect of Pigment Epithelium-Derived Factor-Impregnated Nanoparticles in P23H Transgenic Rat Retina
G. Akiyama; T. Sakai; N. Kuno; E. Kimura; K. Okano; H. Kohno; M. Ozaki; H. Tsuneoka
Author Affiliations & Notes
  • G. Akiyama
    Ophthalmology, Jikei University School of Medicine, Tokyo, Japan
  • T. Sakai
    Ophthalmology, Jikei University School of Medicine, Tokyo, Japan
  • N. Kuno
    Research and Development Center, Santen Pharmaceutical Co., Ltd, Nara, Japan
  • E. Kimura
    Research and Development Center, Santen Pharmaceutical Co., Ltd, Nara, Japan
  • K. Okano
    Ophthalmology, Jikei University School of Medicine, Tokyo, Japan
  • H. Kohno
    Ophthalmology, Jikei University School of Medicine, Tokyo, Japan
  • M. Ozaki
    Ophthalmology, Jikei University School of Medicine, Tokyo, Japan
  • H. Tsuneoka
    Ophthalmology, Jikei University School of Medicine, Tokyo, Japan
  • Footnotes
    Commercial Relationships  G. Akiyama, None; T. Sakai, None; N. Kuno, None; E. Kimura, None; K. Okano, None; H. Kohno, None; M. Ozaki, None; H. Tsuneoka, None.
  • Footnotes
    Support  None.
Investigative Ophthalmology & Visual Science April 2009, Vol.50, 692. doi:
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      G. Akiyama, T. Sakai, N. Kuno, E. Kimura, K. Okano, H. Kohno, M. Ozaki, H. Tsuneoka; Effect of Pigment Epithelium-Derived Factor-Impregnated Nanoparticles in P23H Transgenic Rat Retina. Invest. Ophthalmol. Vis. Sci. 2009;50(13):692.

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Abstract

Purpose: : To investigate the protective effect of intravitreal injection of pigment epithelium-derived factor-impregnated nanoparticles (PEDF-NPs) against photoreceptor degeneration in P23H transgenic rats.

Methods: : Six-week-old P23H rats received an intravitreal injection of PBS, blank NPs, PEDF (2.5 µg) or PEDF-NPs (2.5 µg). Eyes were assessed by morphological and immunohistochemical analysis over the following 8 weeks.

Results: : Immunocytochemistry did not exhibit greater opsin preservation in PEDF-NPs-treated retinas, and a significantly higher number of photoreceptors, compared to blank NPs-treated retinas.

Conclusions: : The results suggest that intravitreally injected PEDF-NPs did not prevent photoreceptor degeneration in the P23H rat retina.

Keywords: photoreceptors • retinal degenerations: cell biology • retinal glia 
© 2009, The Association for Research in Vision and Ophthalmology, Inc., all rights reserved. Permission to republish any abstract or part of an abstract in any form must be obtained in writing from the ARVO Office prior to publication.
Copyright © 2025 Association for Research in Vision and Ophthalmology.
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