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V. A. Forsaa, D. H. Engelsvold, J. H. Seland; Photodynamic Therapy for Chronic Central Serous Chorioretinopathy. Long Term Follow Up. Invest. Ophthalmol. Vis. Sci. 2009;50(13):751.
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To evaluate the long term effect of photodynamic therapy (PDT) on chronic central serous chorioretinopathy (CSCR)
A retrospective review of 12 eyes of 12 consecutive patients with chronic CSCR treated with PDT. Treatment was given between September 2003 and October 2007. Main outcome measures are change in visual acuity (VA) and presence of subretinal fluid (SRF). Visual acuity measurements were obtained using Snellen charts or Early Treatment Diabetic Retinopathy Study (ETDRS) LogMAR charts. Snellen VA values were converted into logMAR units for statistical analyses. Optical coherence tomography (OCT) scans, fundus colorphotographs, fluoreceine- and indocyanin-angiographies were assessed for SRF, leaking patterns and other characteristics.
7 males and 5 females were included in this study. Mean age was 53,9 years. Mean delay from debut of symptoms to PDT was 58,1 months (6 - 264) and mean follow up was 21,9 months (4 - 39). 5 cases had focal and 7 cases diffuse leakage on fluoreceine angiography. Pre-treatment, 12 of 12 patients had subretinal fluid confirmed either by OCT, ophthalmoscopy or fluoresceine angiography. Subretinal fluid disappeared in all cases after a mean of 2,7 months (0,5 - 9,7). Pretreatment mean VA was LogMAR 0,55 and mean final VA was LogMAR 0,23. The change in VA is statistical significant (p = 0,014).
In our study, long-term results after PDT for chronic CSCR showed improved VA and disappearance of subretinal fluid. However, the retrospective, non random nature of this study should be considered before drawing conclusions.
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