April 2009
Volume 50, Issue 13
ARVO Annual Meeting Abstract  |   April 2009
Idiopathic Pigment Epithelial Detachment Clinical Characteristics
Author Affiliations & Notes
  • P. N. Youssef
    Ophthalmology, University of Wisconsin-Madison, Madison, Wisconsin
  • J. Gunther
    Ophthalmology, University of Wisconsin-Madison, Madison, Wisconsin
  • M. Altaweel
    Ophthalmology, University of Wisconsin-Madison, Madison, Wisconsin
  • Footnotes
    Commercial Relationships  P.N. Youssef, None; J. Gunther, None; M. Altaweel, None.
  • Footnotes
    Support  None.
Investigative Ophthalmology & Visual Science April 2009, Vol.50, 758. doi:
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    • Get Citation

      P. N. Youssef, J. Gunther, M. Altaweel; Idiopathic Pigment Epithelial Detachment Clinical Characteristics. Invest. Ophthalmol. Vis. Sci. 2009;50(13):758.

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      © ARVO (1962-2015); The Authors (2016-present)

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Purpose: : To describe the clinical characteristics of idiopathic retinal pigment epithelium detachments (PED) in 10 patients.

Methods: : Retrospective case series

Results: : Retinal pigment epithelium detachments occur predominantly in association with age-related macular degeneration but have been found with central serous chorioretinopathy, leukemia, and other retinal disorders. We report PEDs in 12 eyes of 10 patients (7 female) without any known predisposition for PED formation. All PEDs were confirmed with OCT and FA. The average age was 47.7 years with a median of 46.6 years. The appearance of the PEDs varied from clear to more obvious yellowish lesions (Fig 1). Seven of 12 eyes had multiple PEDs. There was no evidence of AMD, Best's disease, or pattern dystrophy. Over a 3 year mean follow-up, patients maintained good visual acuity (20/15 to 20/40). One patient developed subretinal fluid and CSCR. Recovery to 20/20 accompanied resolution of SRF. The appearance of PED lesions on OCT were typical for serous PEDs seen in other diseases such as ARMD (Fig 2). FA revealed prompt filling and late pooling. OCT and FA appearance remained stable on follow up.

Conclusions: : Patients with idiopathic PEDs have a much higher female to male ratio than found with CSCR and a younger age range than ARMD. Lesions and visual acuity maintain a stable clinical course. The appearance of subsequent CSCR in one patient indicates that prior or incipient CSCR must be considered in the differential diagnosis of idiopathic PED.

Keywords: retinal pigment epithelium • macula/fovea • imaging/image analysis: clinical 

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