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I. K. Petropoulos, M. A. Matter, P. M. Desmangles; A Possible Role of Posterior Vitreomacular Adhesion in the Development of Adult-Onset Foveomacular Vitelliform Dystrophy: A Study With Spectral-Domain Optical Coherence Tomography. Invest. Ophthalmol. Vis. Sci. 2009;50(13):759.
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To assess the prevalence of vitreomacular interface abnormalities in patients with adult-onset foveomacular vitelliform dystrophy (AOFVD).
Consecutive patients presenting with AOFVD between January 2007 and October 2008 were recruited. Fundus biomicroscopic examination and serial scans of the macula using spectral-domain optical coherence tomography (OCT) (Copernicus SOCT, Optopol) were performed. The presence of vitreomacular traction or epiretinal membrane was determined.
Fifteen eyes of 11 consecutive patients (7 men and 4 women; mean age 81 years, range 69 to 92 years) with AOFVD were included. The vitelliform lesion was unilateral in 7 patients and bilateral in 4 patients. Vitreomacular interface abnormalities were detected in 11 eyes (73%), including 6 eyes (40%) presenting an epiretinal membrane (Figure 1) and 5 eyes (33%) showing signs of vitreomacular traction (Figure 2) on OCT. In one patient, spontaneous resolution of vitreomacular traction led to progressive significant decrease in the size of the vitelliform lesion and to improvement of vision over 10 months.
Spectral-domain OCT reveals a high prevalence of vitreomacular interface abnormalities in patients with AOFVD, suggesting for the first time an important role of posterior vitreomacular adhesion in the development of a vitelliform lesion in the macular area.
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