April 2009
Volume 50, Issue 13
Free
ARVO Annual Meeting Abstract  |   April 2009
Subscleral Implantation of Orbital Adipocytes for Atrofic Macular Degeneration: An Experimental Model
L. Scorolli; S. Z. Scalinci; A. Meduri; R. A. Meduri; A. P. Ciardella; R. M. Gaudiano; M. Morara
Author Affiliations & Notes
  • L. Scorolli
    Ophthalmology, S.Orsola Malpighi Hospital Bologna, Bologna, Italy
  • S. Z. Scalinci
    Ophthalmology, S.Orsola Malpighi Hospital Bologna, Bologna, Italy
  • A. Meduri
    Ophthalmology, S.Orsola Malpighi Hospital Bologna, Bologna, Italy
  • R. A. Meduri
    Ophthalmology, S.Orsola Malpighi Hospital Bologna, Bologna, Italy
  • A. P. Ciardella
    Ophthalmology, S.Orsola Malpighi Hospital Bologna, Bologna, Italy
  • R. M. Gaudiano
    Ophthalmology, S.Orsola Malpighi Hospital Bologna, Bologna, Italy
  • M. Morara
    Ophthalmology, S.Orsola Malpighi Hospital Bologna, Bologna, Italy
  • Footnotes
    Commercial Relationships  L. Scorolli, None; S.Z. Scalinci, None; A. Meduri, None; R.A. Meduri, None; A.P. Ciardella, None; R.M. Gaudiano, None; M. Morara, None.
  • Footnotes
    Support  None.
Investigative Ophthalmology & Visual Science April 2009, Vol.50, 782. doi:
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      L. Scorolli, S. Z. Scalinci, A. Meduri, R. A. Meduri, A. P. Ciardella, R. M. Gaudiano, M. Morara; Subscleral Implantation of Orbital Adipocytes for Atrofic Macular Degeneration: An Experimental Model. Invest. Ophthalmol. Vis. Sci. 2009;50(13):782.

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Abstract

Purpose: : to evaluate action of subscleral adipocytes implantation in establishing a gradient of bFGF in the retinal tissue

Methods: : we perform the surgical procedure in 16 mice affected by atrophic age-related macular degeneration (AMD). Controlater eye served as control.

Results: : examinations were performed every 1, 3, 6, 12 and 18 months from surgery and an increase of retinal trophism resulted. Intra-operative or postoperative complications did not occurr.

Conclusions: : subscleral adipocytes implantation could affect retinal and vitreal levels of bFGF. Further studies should be performed for degenerative pathologies charachterized by retinal cells apoptosis.

Keywords: age-related macular degeneration 
© 2009, The Association for Research in Vision and Ophthalmology, Inc., all rights reserved. Permission to republish any abstract or part of an abstract in any form must be obtained in writing from the ARVO Office prior to publication.
Copyright © 2025 Association for Research in Vision and Ophthalmology.
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