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L. Kagemann, G. Wollstein, H. Ishikawa, R. A. Bilonick, M. L. Gabriele, L. S. Folio, J. G. Fujimoto, J. S. Schuman; Schlemm’s Canal (SC) Cross-Sectional Area Increases at Collector Channel Junctions. Invest. Ophthalmol. Vis. Sci. 2009;50(13):813.
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Segmental SC aqueous flow would present with closed-off and open SC segments, and pooling of aqueous near SC and collector channel (CC) junctions (SC/CC). Circumferential flow would present with a generally open SC. The purpose of this study was to non-invasively compare cross-sectional SC areas at, and away from, SC/CC’s human eyes in-vivo.
SC was imaged with Bioptigen (Bioptigen Inc, USA) spectral-domain optical coherence tomography and a 200 nm bandwidth broadlighter (SuperLum LTD., Ireland) in cross-section in both eyes of 14 healthy subjects at 3 and 9 o’clock. CC’s were tracked to the SC/CC. Ten frames (700 1.3mm A-scans x 0.6 mm) centered at the SC/CC were recorded. (Figure) Eighteen sequential A-scans were averaged for structural imaging. Frame sequences contained both a SC/CC and an adjacent area of SC with a visible disconnect from the junction. (Figure) Contrast and magnification were adjusted to maximize visualization. SC was traced 3 times in ImageJ (ImageJ 1.40g, http://rsb.info.nih.gov/ij/) and mean SC area was recorded. The SC area, on or off SC/CC, and OD/OS and nasal/temporal laterality were analyzed by a linear mixed effects model.
SC area was significantly larger on SC/CC’s than off (12,890 vs. 7,391 µm2, 95% confidence interval (CI) of the difference: 3,871 - 6,229; p < 0.0001). SC was significantly larger on the nasal side (10,983 vs 8,308 µm2; 95% CI of the difference: 441 - 2,773 p = 0.009) than temporal.
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