April 2009
Volume 50, Issue 13
Free
ARVO Annual Meeting Abstract  |   April 2009
Schlemm’s Canal (SC) Cross-Sectional Area Increases at Collector Channel Junctions
L. Kagemann; G. Wollstein; H. Ishikawa; R. A. Bilonick; M. L. Gabriele; L. S. Folio; J. G. Fujimoto; J. S. Schuman
Author Affiliations & Notes
  • L. Kagemann
    UPMC Eye Center, Eye and Ear Institute, Ophthalmology and Visual Science Research Center, Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania
    Department of Bioengineering, University of Pittsburgh, Swanson School of Engineering, Pittsburgh, Pennsylvania
  • G. Wollstein
    UPMC Eye Center, Eye and Ear Institute, Ophthalmology and Visual Science Research Center, Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania
  • H. Ishikawa
    UPMC Eye Center, Eye and Ear Institute, Ophthalmology and Visual Science Research Center, Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania
    Department of Bioengineering, University of Pittsburgh, Swanson School of Engineering, Pittsburgh, Pennsylvania
  • R. A. Bilonick
    UPMC Eye Center, Eye and Ear Institute, Ophthalmology and Visual Science Research Center, Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania
  • M. L. Gabriele
    UPMC Eye Center, Eye and Ear Institute, Ophthalmology and Visual Science Research Center, Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania
    Department of Bioengineering, University of Pittsburgh, Swanson School of Engineering, Pittsburgh, Pennsylvania
  • L. S. Folio
    UPMC Eye Center, Eye and Ear Institute, Ophthalmology and Visual Science Research Center, Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania
  • J. G. Fujimoto
    Dept. of Electrical Engineering and Computer Science and Research Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, Massachusetts
  • J. S. Schuman
    UPMC Eye Center, Eye and Ear Institute, Ophthalmology and Visual Science Research Center, Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania
    Department of Bioengineering, University of Pittsburgh, Swanson School of Engineering, Pittsburgh, Pennsylvania
  • Footnotes
    Commercial Relationships  L. Kagemann, None; G. Wollstein, Carl Zeiss Meditec, F; Optovue, F; Bioptigen, P; H. Ishikawa, Bioptigen, P; R.A. Bilonick, None; M.L. Gabriele, None; L.S. Folio, None; J.G. Fujimoto, Optovue, I; Carl Zeiss Meditec, P; J.S. Schuman, Pfizer, R; Merck, R; Lumenis, R; Optovue, R; Bioptigen, P; Carl Zeiss Meditec, P; Alcon, R; Allergan, R; Carl Zeiss Meditec, R; Heidelberg Engineering, R.
  • Footnotes
    Support  NIH R01-EY013178-8, P30-EY008098; Eye and Ear Foundation (Pittsburgh, PA); Research to Prevent Blindness
Investigative Ophthalmology & Visual Science April 2009, Vol.50, 813. doi:
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      L. Kagemann, G. Wollstein, H. Ishikawa, R. A. Bilonick, M. L. Gabriele, L. S. Folio, J. G. Fujimoto, J. S. Schuman; Schlemm’s Canal (SC) Cross-Sectional Area Increases at Collector Channel Junctions. Invest. Ophthalmol. Vis. Sci. 2009;50(13):813.

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Abstract

Purpose: : Segmental SC aqueous flow would present with closed-off and open SC segments, and pooling of aqueous near SC and collector channel (CC) junctions (SC/CC). Circumferential flow would present with a generally open SC. The purpose of this study was to non-invasively compare cross-sectional SC areas at, and away from, SC/CC’s human eyes in-vivo.

Methods: : SC was imaged with Bioptigen (Bioptigen Inc, USA) spectral-domain optical coherence tomography and a 200 nm bandwidth broadlighter (SuperLum LTD., Ireland) in cross-section in both eyes of 14 healthy subjects at 3 and 9 o’clock. CC’s were tracked to the SC/CC. Ten frames (700 1.3mm A-scans x 0.6 mm) centered at the SC/CC were recorded. (Figure) Eighteen sequential A-scans were averaged for structural imaging. Frame sequences contained both a SC/CC and an adjacent area of SC with a visible disconnect from the junction. (Figure) Contrast and magnification were adjusted to maximize visualization. SC was traced 3 times in ImageJ (ImageJ 1.40g, http://rsb.info.nih.gov/ij/) and mean SC area was recorded. The SC area, on or off SC/CC, and OD/OS and nasal/temporal laterality were analyzed by a linear mixed effects model.

Results: : SC area was significantly larger on SC/CC’s than off (12,890 vs. 7,391 µm2, 95% confidence interval (CI) of the difference: 3,871 - 6,229; p < 0.0001). SC was significantly larger on the nasal side (10,983 vs 8,308 µm2; 95% CI of the difference: 441 - 2,773 p = 0.009) than temporal.

Clinical Trial: : www.clinicaltrials.gov NCT00343473

Keywords: aqueous • imaging/image analysis: clinical 
© 2009, The Association for Research in Vision and Ophthalmology, Inc., all rights reserved. Permission to republish any abstract or part of an abstract in any form must be obtained in writing from the ARVO Office prior to publication.
Copyright © 2025 Association for Research in Vision and Ophthalmology.
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