Abstract
Purpose: :
Correlation of peripapillary retinal nerve fiber layer thickness by spectral domain & time domain optical coherence tomography (OCT) with automated visual fields in patient with optic nerve head drusen.
Methods: :
This is an institutional review board approved prospective study of 16 eyes with optic nerve head drusen & controls. After informed consent, complete medical history, ophthalmology examination, B scan ultrasonography,automated visual field, peripapillary retinal nerve fiber layer analysis (spectral and time domain OCT) was performed on all subjects (healthy and patients with optic nerve head drusens).
Results: :
Spectral domain & time domain OCT measured RNFLT were significantly predictive of automated visual fields defects for superior and inferior segments (p< 0.05) in patients with optic nerve head drusen. The superior and inferior retinal nerve fiber layer thickness were significantly thinner in optic nerve head drusen eyes as compared to controls (p<0.01). Across normal patients and those with disease (n = 21), there were strong statistically significant correlations between spectral domain and time domain OCT measurements for both superior (r = 0.94, p < .001) and inferior (r = 0.91, p < .001) retinal nerve fiber layer readings. Regression analyses demonstrated that disease status does not affect the correlation for superior (p = .350) or inferior (p = .227) retinal nerve fiber layer. . Drusen grade & maximum intra ocular pressure were not predictive of automated visual fields defect.
Conclusions: :
Spectral domain & time domain OCT reliably measures retinal nerve fiber layer thickness correlating with automated visual fields.
Keywords: optic disc • nerve fiber layer • imaging methods (CT, FA, ICG, MRI, OCT, RTA, SLO, ultrasound)