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V. A. Shah, N. R. Sabates, A. J. Bonham, R. Krishna; Correlation of Automated Visual Fields, Spectral Domain and Time Domain Optical Coherence Tomography Findings in Eyes With Optic Nerve Head Drusen. Invest. Ophthalmol. Vis. Sci. 2009;50(13):935.
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Correlation of peripapillary retinal nerve fiber layer thickness by spectral domain & time domain optical coherence tomography (OCT) with automated visual fields in patient with optic nerve head drusen.
This is an institutional review board approved prospective study of 16 eyes with optic nerve head drusen & controls. After informed consent, complete medical history, ophthalmology examination, B scan ultrasonography,automated visual field, peripapillary retinal nerve fiber layer analysis (spectral and time domain OCT) was performed on all subjects (healthy and patients with optic nerve head drusens).
Spectral domain & time domain OCT measured RNFLT were significantly predictive of automated visual fields defects for superior and inferior segments (p< 0.05) in patients with optic nerve head drusen. The superior and inferior retinal nerve fiber layer thickness were significantly thinner in optic nerve head drusen eyes as compared to controls (p<0.01). Across normal patients and those with disease (n = 21), there were strong statistically significant correlations between spectral domain and time domain OCT measurements for both superior (r = 0.94, p < .001) and inferior (r = 0.91, p < .001) retinal nerve fiber layer readings. Regression analyses demonstrated that disease status does not affect the correlation for superior (p = .350) or inferior (p = .227) retinal nerve fiber layer. . Drusen grade & maximum intra ocular pressure were not predictive of automated visual fields defect.
Spectral domain & time domain OCT reliably measures retinal nerve fiber layer thickness correlating with automated visual fields.
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