April 2009
Volume 50, Issue 13
Free
ARVO Annual Meeting Abstract  |   April 2009
Relationship Between Spectral Domain OCT Determined Drusen Volume in AMD and AREDS Classification
S. R. Freeman; I. Kozak; L. Cheng; D.-U. Bartsch; F. Mojana; N. Nigam; M. Brar; R. Yuson; W. R. Freeman
Author Affiliations & Notes
  • S. R. Freeman
    Ophthalmology, University of California, San Diego, Jacobs Retina Center, La Jolla, California
  • I. Kozak
    Ophthalmology, University of California, San Diego, Jacobs Retina Center, La Jolla, California
  • L. Cheng
    Ophthalmology, University of California, San Diego, Jacobs Retina Center, La Jolla, California
  • D.-U. Bartsch
    Ophthalmology, University of California, San Diego, Jacobs Retina Center, La Jolla, California
  • F. Mojana
    Ophthalmology, University of California, San Diego, Jacobs Retina Center, La Jolla, California
  • N. Nigam
    Ophthalmology, University of California, San Diego, Jacobs Retina Center, La Jolla, California
  • M. Brar
    Ophthalmology, University of California, San Diego, Jacobs Retina Center, La Jolla, California
  • R. Yuson
    Ophthalmology, University of California, San Diego, Jacobs Retina Center, La Jolla, California
  • W. R. Freeman
    Ophthalmology, University of California, San Diego, Jacobs Retina Center, La Jolla, California
  • Footnotes
    Commercial Relationships  S.R. Freeman, None; I. Kozak, None; L. Cheng, None; D.-U. Bartsch, None; F. Mojana, None; N. Nigam, None; M. Brar, None; R. Yuson, None; W.R. Freeman, None.
  • Footnotes
    Support  NIH, WRF, DUB
Investigative Ophthalmology & Visual Science April 2009, Vol.50, 940. doi:
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      S. R. Freeman, I. Kozak, L. Cheng, D.-U. Bartsch, F. Mojana, N. Nigam, M. Brar, R. Yuson, W. R. Freeman; Relationship Between Spectral Domain OCT Determined Drusen Volume in AMD and AREDS Classification. Invest. Ophthalmol. Vis. Sci. 2009;50(13):940.

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Abstract

Purpose: : Drusen are the hallmark of age-related macular degeneration (AMD) and substantial evidence exists that the amount of drusen and their effect on retinal pigment is a strong predictor of progression of AMD and vision loss. Until recently it was not possible to quantitate the volume of the drusen; however, the use of image stabilized scanning laser ophthalmoscope/spectral domain optical coherence tomography (SLO/ SD OCT) has enabled determination of drusen volume of this abnormal material. The purpose was to assess the correlation of drusen volume with Age-Related Eye Disease Study (AREDS) grade and drusen area in dry AMD.

Methods: : 36 eyes from patients with non-exudative AMD with visual acuity between 20/16 and 20/160 ETDRS were studied. Spectral Domain OCT/simultaneous OCT scans were taken as were color fundus photographs (35 degrees) of each eye. ETDRS visions were also recorded. The full AREDS Score excluding late stage AMD was determined by agreement between 2 trained observers. Drusen volume was determined by examination of a series of 96 SD OCT scans taken from arcade to arcade for a length of 6 mm. Volume was determined by calculating the drusen area in each scan and determining the drusen volume by calculating the effective volume of each cut using NIH Image J. Drusen were identified and outlined manually, not using an automated algorithm.

Results: : There was a strong and significant correlation between drusen volume and AREDS determined drusen area (p<0.0001, r=0.78). In addition, there was a correlation between AREDS classification and drusen volume (p=0.023, r=0.43) as determined by pair-wise correlation.

Conclusions: : Drusen volume as determined by SD-OCT correlates with AREDS determined drusen area and AREDS grade in non-exudative AMD. The correlation is not perfect, however, as drusen area and volume average for 40% and 82% of the variation, respectively. Spectral Domain OCT determined drusen volume appears to provide additional information in grading severity of eyes with dry AMD.

Keywords: age-related macular degeneration • imaging/image analysis: clinical • image processing 
© 2009, The Association for Research in Vision and Ophthalmology, Inc., all rights reserved. Permission to republish any abstract or part of an abstract in any form must be obtained in writing from the ARVO Office prior to publication.
Copyright © 2025 Association for Research in Vision and Ophthalmology.
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