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P. Fonseca, A. Santos, R. Bernardes, R. Silva, S. Carvajal-Gonzalez, R. Buggage, J. Cunha-Vaz; Conversion to Wet Age-Related Macular Degeneration in a 2-Year Prospective, Observational Study of Fellow Eyes of Patients With Unilateral Wet Age-Related Macular Degeneration. Invest. Ophthalmol. Vis. Sci. 2009;50(13):946.
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To investigate markers of development of choroidal neovascularization (CNV) in fellow eyes of subjects with unilateral wet age-related macular degeneration (AMD) enrolled in a 2 year prospective, observational study.
Sixty-two subjects over 50 years with unilateral wet AMD in one eye were enrolled in a study to be evaluated with ETDRS visual acuity, complete ophthalmic examination, fundus photography, fluorescein and indocyanine green angiography (FA, ICG-A), ocular coherence tomography (OCT), fundus autofluorescence (FAF) and retinal leakage analysis at baseline and thereafter every 6 months for a period of 2 years or until development of CNV was confirmed by FA. Morphological characteristics before conversion of patients who developed CNV are reviewed.
Of the 62 patients enrolled, 52 completed the study according to protocol, with 17 (27,4%) converting to wet AMD and 35 patients completing the 2-year follow-up without conversion. All 17 eyes showed changes in OCT at the time of conversion. Before conversion, 4 of the 17 eyes showed changes on ICG and 14 of the 17 eyes showed alterations in the Blood-Retinal Barrier on RLA. No clear pattern on fundus photography and FAF was associated with conversion to wet AMD.
In this 2-year prospective study 27,4% of enrolled patients developed wet AMD in the study eye. ICG and RLA showed alterations before conversion suggesting that these procedures may predict earlier conversion to wet AMD.
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